All Phenotypes Tg(HRAS)2Jic MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Irf1^tm1Mak/Irf1^tm1Mak Tg(HRAS)2Jic/?	involves: 129S2/SvPas * BALB/c * C57BL/6	MGI:4819237
cx2	Flt4^tm1.1Ichi/Flt4⁺ Tg(HRAS)2Jic/0	involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2	MGI:4821322
cx3	Flt4^tm1.1Ichi/Flt4⁺ Kras^tm1Mok/Kras⁺ Tg(HRAS)2Jic/0	involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2	MGI:4821326
cx4	Hras^tm1Mok/Hras^tm1Mok Kras^tm1Mok/Kras⁺ Nras^tm1Mok/Nras⁺ Tg(HRAS)2Jic/0	involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2	MGI:4821330
cx5	Hras^tm1Mok/Hras^tm1Mok Nras^tm1Mok/Nras^tm1Mok Tg(HRAS)2Jic/0	involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2	MGI:4821332
cx6	Kras^tm1Mok/Kras⁺ Nras^tm1Mok/Nras^tm1Mok Tg(HRAS)2Jic/0	involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2	MGI:4821336
tg7	Tg(HRAS)2Jic/?	involves: BALB/c * C57BL/6	MGI:4819236

Allelic Composition	Irf1^tm1Mak/Irf1^tm1Mak Tg(HRAS)2Jic/?
Genetic Background	involves: 129S2/SvPas * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf1^tm1Mak mutation (1 available); any Irf1 mutation (19 available)
Tg(HRAS)2Jic mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor incidence ( J:55418 )

• 44% develop tumors as compared to 7% of controls

increased hemangiosarcoma incidence ( J:55418 )

• angiosarcomas observed most frequently

Allelic Composition	Flt4^tm1.1Ichi/Flt4⁺ Tg(HRAS)2Jic/0
Genetic Background	involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt4^tm1.1Ichi mutation (0 available); any Flt4 mutation (76 available)
Tg(HRAS)2Jic mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:159024 )

N	• no mice exhibit chylous ascites

Allelic Composition	Flt4^tm1.1Ichi/Flt4⁺ Kras^tm1Mok/Kras⁺ Tg(HRAS)2Jic/0
Genetic Background	involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt4^tm1.1Ichi mutation (0 available); any Flt4 mutation (76 available)
Kras^tm1Mok mutation (6 available); any Kras mutation (76 available)
Tg(HRAS)2Jic mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

chylous ascites ( J:159024 )

• 1 of 13 mice develop chylous ascites unlike wild-type mice

immune system

lymphatic vessel hypoplasia ( J:159024 )

• a few mice exhibit lymphatic vessel hypoplasia

Allelic Composition	Hras^tm1Mok/Hras^tm1Mok Kras^tm1Mok/Kras⁺ Nras^tm1Mok/Nras⁺ Tg(HRAS)2Jic/0
Genetic Background	involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hras^tm1Mok mutation (15 available); any Hras mutation (30 available)
Kras^tm1Mok mutation (6 available); any Kras mutation (76 available)
Nras^tm1Mok mutation (7 available); any Nras mutation (44 available)
Tg(HRAS)2Jic mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:159024 )

N	• no mice exhibit chylous ascites

Allelic Composition	Hras^tm1Mok/Hras^tm1Mok Nras^tm1Mok/Nras^tm1Mok Tg(HRAS)2Jic/0
Genetic Background	involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hras^tm1Mok mutation (15 available); any Hras mutation (30 available)
Nras^tm1Mok mutation (7 available); any Nras mutation (44 available)
Tg(HRAS)2Jic mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:159024 )

N	• no mice exhibit chylous ascites

Allelic Composition	Kras^tm1Mok/Kras⁺ Nras^tm1Mok/Nras^tm1Mok Tg(HRAS)2Jic/0
Genetic Background	involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm1Mok mutation (6 available); any Kras mutation (76 available)
Nras^tm1Mok mutation (7 available); any Nras mutation (44 available)
Tg(HRAS)2Jic mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:159024 )

N	• no mice exhibit chylous ascites

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

skeletal muscle fiber necrosis ( J:99371 )

• scattered

mortality/aging

decreased survivor rate ( J:73016 )

• 77 week survival rate for males is 53% and for females is 32%

limbs/digits/tail

abnormal limb muscle morphology ( J:135606 )

• skeletal myopathy in femoral muscle

• heart tongue and esophagus muscles are normal

growth/size/body

decreased body weight ( J:135606 )

• body weights up to 36 weeks of age are between 80 and 100% of controls

neoplasm

neoplasm ( J:64968 )

N	• no tumors or pre-neoplasias among F2 mice within the first 6 months

abnormal tumor morphology ( J:64968 )

• point mutations often found in transgene in cells from tumors

increased tumor incidence ( J:64968 )

• 24/50 F2 mice develop tumors within 18 months

• 6/24 F2 mice that developed tumors developed double tumors

increased incidence of tumors by chemical induction ( J:73016 , J:101590 )

• N-methyl-N-nitrosourea (MNU) induced tumors involve point mutations in transgene while ENU induced tumors do not (J:73016)

• transgene overexpression in tumors induced by MNU, ENU, and urethane (J:73016)

• incidence of chemically induced lung adenomas and hyperplasia is higher than in controls (J:101590)

• chemical induction of papillomas and squamous cell carcinomas of the forestomach are common (J:101590)

• chemically induced hemangiosarcomas of the esophagus and small intestine are common (J:101590)

increased classified tumor incidence ( J:64968 )

increased skin papilloma incidence ( J:64968 )

• one example within 3 months

• 3 skin papillomas in 50 F2 mice

increased lymphoma incidence ( J:64968 )

• 2 lymphomas in 50 F2 mice

increased adenocarcinoma incidence ( J:64968 )

• 4 harderian gland adenocarcinomas in 50 F2 mice

increased lung adenocarcinoma incidence ( J:64968 )

• 8 lung adenocarcinomas in 50 F2 mice

increased sarcoma incidence ( J:64968 )

• founder and 2 of 20 F1 mice develop angiosarcoma within 5 months

• 13 angiosarcomas in 50 F2 mice

respiratory system

increased lung adenocarcinoma incidence ( J:64968 )

• 8 lung adenocarcinomas in 50 F2 mice

muscle

abnormal skeletal muscle morphology ( J:99371 )

• myopathic changes seen at 10-13 weeks in biceps femoris, gastrocnemius, and triceps brachii

• increased cell density occasionally

• diaphragm and soleus are normal

abnormal limb muscle morphology ( J:135606 )

• skeletal myopathy in femoral muscle

• heart tongue and esophagus muscles are normal

abnormal skeletal muscle fiber morphology ( J:99371 )

• biceps femoris is most susceptible to myopathic changes

• internal architecture of muscle fibers becomes disorganized

skeletal muscle fiber necrosis ( J:99371 )

• scattered

increased variability of skeletal muscle fiber size ( J:99371 )

centrally nucleated skeletal muscle fibers ( J:99371 )

skeletal muscle fiber degeneration ( J:99371 , J:135606 )

• scattered (J:99371)

• some hyaline degeneration of muscle fibers observed (J:135606)

abnormal pectoral muscle morphology ( J:135606 )

• skeletal myopathy

skeletal muscle interstitial fibrosis ( J:135606 )

• some increase in interstitial collagen fibers

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:73016 , J:101590 )

• N-methyl-N-nitrosourea (MNU) induced tumors involve point mutations in transgene while ENU induced tumors do not (J:73016)

• transgene overexpression in tumors induced by MNU, ENU, and urethane (J:73016)

• incidence of chemically induced lung adenomas and hyperplasia is higher than in controls (J:101590)

• chemical induction of papillomas and squamous cell carcinomas of the forestomach are common (J:101590)

• chemically induced hemangiosarcomas of the esophagus and small intestine are common (J:101590)

integument

increased skin papilloma incidence ( J:64968 )

• one example within 3 months

• 3 skin papillomas in 50 F2 mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23