Phenotypes associated with this allele

• Allele Symbol: Tg(Apcs-Lep)1Yog
• Allele Name: transgene insertion 1, Yoshihiro Ogawa
• Allele ID: MGI:3039276
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Apcs-Lep)1Yog/0	involves: C57BL/6 * DBA/2	MGI:3039490
tg2	Tg(Apcs-Lep)1Yog/0	involves: C57BL/6J * FVB/N	MGI:3039495
tg3	Tg(Apcs-Lep)1Yog/0	Not Specified	MGI:3039493
tg4	Tg(Apcs-Lep)1Yog/?	involves: C57BL/6 * DBA/2	MGI:4429456

Genotype
MGI:3039490

tg1

• Allelic Composition: Tg(Apcs-Lep)1Yog/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased brown adipose tissue amount ( J:57075 )

• brown adipose tissue develops normally but disappears by 3 weeks of age

decreased white adipose tissue amount ( J:57075 )

• transgenic develop no white adipose tissue

behavior/neurological

abnormal food intake ( J:57075 )

• transgenic mice eat less than non-transgenic mice

endocrine/exocrine glands

small pancreatic islets ( J:57075 )

• the size of the islets is markedly reduced compared to pair-fed non-transgenic littermates

growth/size/body

decreased body weight ( J:57075 )

• 4-week old transgenic mice weigh significantly less than non-transgenic mice

homeostasis/metabolism

abnormal glucose homeostasis ( J:57075 )

decreased circulating insulin level ( J:57075 )

• insulin concentrations are significantly decreased compared to pair-fed non-transgenic littermates

decreased liver glycogen level ( J:57075 )

• at 17 weeks the liver glycogen content is significantly less in transgenic mice than in non-transgenic littermates

increased insulin sensitivity ( J:57075 )

• after glucose injection the increase in serum glucose levels is less than that in fed non-transgenic littermates

• after insulin injection the hyper glycemic response is seen faster in transgenic mice than in non-transgenic littermates

abnormal lipid level ( J:57075 )

decreased circulating triglyceride level ( J:57075 )

• plasma triglyceride levels are significantly decreased compared to pair-fed non-transgenic littermates

decreased liver triglyceride level ( J:57075 )

• liver triglyceride levels are significantly decreased compared to pair-fed non-transgenic littermates

liver/biliary system

decreased liver glycogen level ( J:57075 )

• at 17 weeks the liver glycogen content is significantly less in transgenic mice than in non-transgenic littermates

decreased liver triglyceride level ( J:57075 )

• liver triglyceride levels are significantly decreased compared to pair-fed non-transgenic littermates

decreased liver weight ( J:57075 )

• at 17 weeks the liver weight in transgenic mice is significantly less than that in pair-fed non-transgenic littermates

Genotype
MGI:3039495

tg2

• Allelic Composition: Tg(Apcs-Lep)1Yog/0
• Genetic Background: involves: C57BL/6J * FVB/N

adipose tissue

decreased brown adipose tissue amount ( J:69591 )

• the amount of interscapular brown adipose tissue is reduced compared to non-transgenic littermates

• the interscapular brown adipose tissue is more eosinophilic than that in to non-transgenic littermates

decreased white adipose tissue amount ( J:69591 )

• no subcutaneous white adipose tissue is seen in transgenic mice

behavior/neurological

abnormal food intake ( J:69591 )

• food intake is significantly reduced in transgenic mice reduced compared to non-transgenic littermates

endocrine/exocrine glands

small pancreatic islets ( J:69591 )

• the size of the pancreatic islets is reduced in transgenic mice compared to non-transgenic littermates

growth/size/body

decreased body weight ( J:69591 )

• transgenic mice are thinner than non-transgenic littermates

• by 4 weeks transgenic mice are significantly smaller than non-transgenic littermates

homeostasis/metabolism

abnormal glucose homeostasis ( J:69591 )

decreased circulating glucose level ( J:69591 )

• fed plasma glucose is lower in transgenic mice than in non-transgenic littermates

decreased circulating insulin level ( J:69591 )

• plasma insulin levels are lower in transgenic mice than in non-transgenic littermates

increased insulin sensitivity ( J:69591 )

• glucose and insulin tolerance tests reveal increased insulin sensitivity in transgenic mice compared to non-transgenic littermates

abnormal lipid level ( J:69591 )

decreased circulating free fatty acids level ( J:69591 )

• plasma free fatty acid levels are lower in transgenic mice than in non-transgenic littermates

decreased circulating triglyceride level ( J:69591 )

• plasma triglyceride levels are lower in transgenic mice than in non-transgenic littermates

liver/biliary system

small liver ( J:69591 )

• the liver is smaller in transgenic mice reduced compared to non-transgenic littermates

• the liver is also darker than normal in transgenic mice

Genotype
MGI:3039493

tg3

• Allelic Composition: Tg(Apcs-Lep)1Yog/0
• Genetic Background: Not Specified

skeleton

decreased bone mass ( J:88655 )

• transgenic mice have a significant decrease in bone mass compared to wild-type littermates

Genotype
MGI:4429456

tg4

• Allelic Composition: Tg(Apcs-Lep)1Yog/?
• Genetic Background: involves: C57BL/6 * DBA/2

cardiovascular system

retina neovascularization ( J:92072 )

• neovascularization is significantly increased relative to controls

vision/eye

retina neovascularization ( J:92072 )

• neovascularization is significantly increased relative to controls