Tg(Apcs-Lep)1Yog
Transgene Detail

Summary

• Symbol: Tg(Apcs-Lep)1Yog
• Name: transgene insertion 1, Yoshihiro Ogawa
• MGI ID: MGI:3039276
• Synonyms: LepTg
• Transgene: Tg(Apcs-Lep)1Yog Location: unknown
• Alliance: Tg(Apcs-Lep)1Yog page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Apcs-Lep)1Yog expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Lep (MGI:104663)

• Mutation details: This transgene consists of a mouse Lep cDNA fused to the human Apcs promoter with hormone expression targeted to the liver. In mutants carrying 30 copies of the transgene serum Lep expression is about 12-fold higher than in wild-type mice. (J:57075)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:57075 Ogawa Y, et al., Increased glucose metabolism and insulin sensitivity in transgenic skinny mice overexpressing leptin. Diabetes. 1999 Sep;48(9):1822-9
• All: 12 reference(s)