All Phenotypes Ebf2<tm1Reed> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ebf2^tm1Reed
targeted mutation 1, Randall R Reed
MGI:3037977

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ebf2^tm1Reed/Ebf2^tm1Reed	involves: 129S1/Sv * 129X1/SvJ	MGI:3038082
cx2	Ebf2^tm1Reed/Ebf2⁺ Or8a1b^tm4Mom/Or8a1b⁺	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	MGI:3714645
cx3	Ebf2^tm1Reed/Ebf2⁺ Or8a1^tm26Mom/Or8a1⁺	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	MGI:3714646
cx4	Ebf2^tm1Reed/Ebf2⁺ Ebf3^tm1Reed/Ebf3⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:3038083
cx5	Ebf2^tm1Reed/Ebf2⁺ Zfp423^tm1Reed/Zfp423^tm1Reed	involves: 129S1/Sv * 129X1/SvJ	MGI:3714640

Allelic Composition	Ebf2^tm1Reed/Ebf2^tm1Reed
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ebf2^tm1Reed mutation (0 available); any Ebf2 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:88585 )

• approximately 25% died within the first 3 weeks of life

• additional mice died in the 4th week of life, but in contrast to Ebf3^tm1Reed homozygotes, the majority of mice survived to adulthood

behavior/neurological

abnormal sexual interaction ( J:88585 )

• females showed slightly reduced mating efficiency

• males exhibited a dramatically reduced mating efficiency

nervous system

abnormal olfactory bulb morphology ( J:88585 )

• olfactory glomeruli absent from dorsal olfactory bulb

small olfactory bulb ( J:88585 )

abnormal olfactory neuron innervation pattern ( J:88585 )

• olfactory neurons fail to project to the dorsal olfactory bulb

Allelic Composition	Ebf2^tm1Reed/Ebf2⁺ Or8a1b^tm4Mom/Or8a1b⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ebf2^tm1Reed mutation (0 available); any Ebf2 mutation (30 available)
Or8a1b^tm4Mom mutation (1 available); any Or8a1b mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal olfactory sensory neuron morphology ( J:122275 )

• most olfactory receptor neurons project to multiple more ventral glomeruli

• P2 olfactory receptor neurons extend much shorter axons and project into the ventral region of the bulb

craniofacial

abnormal olfactory sensory neuron morphology ( J:122275 )

• most olfactory receptor neurons project to multiple more ventral glomeruli

• P2 olfactory receptor neurons extend much shorter axons and project into the ventral region of the bulb

respiratory system

abnormal olfactory sensory neuron morphology ( J:122275 )

• most olfactory receptor neurons project to multiple more ventral glomeruli

• P2 olfactory receptor neurons extend much shorter axons and project into the ventral region of the bulb

taste/olfaction

abnormal olfactory sensory neuron morphology ( J:122275 )

• most olfactory receptor neurons project to multiple more ventral glomeruli

• P2 olfactory receptor neurons extend much shorter axons and project into the ventral region of the bulb

growth/size/body

abnormal olfactory sensory neuron morphology ( J:122275 )

• most olfactory receptor neurons project to multiple more ventral glomeruli

• P2 olfactory receptor neurons extend much shorter axons and project into the ventral region of the bulb

Allelic Composition	Ebf2^tm1Reed/Ebf2⁺ Or8a1^tm26Mom/Or8a1⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ebf2^tm1Reed mutation (0 available); any Ebf2 mutation (30 available)
Or8a1^tm26Mom mutation (3 available); any Or8a1 mutation (69 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal olfactory sensory neuron morphology ( J:122275 )

• most olfactory receptor neurons project to multiple more ventral glomeruli

• P2 olfactory receptor neurons extend much shorter axons and project into the ventral region of the bulb

craniofacial

abnormal olfactory sensory neuron morphology ( J:122275 )

• most olfactory receptor neurons project to multiple more ventral glomeruli

• P2 olfactory receptor neurons extend much shorter axons and project into the ventral region of the bulb

respiratory system

abnormal olfactory sensory neuron morphology ( J:122275 )

• most olfactory receptor neurons project to multiple more ventral glomeruli

• P2 olfactory receptor neurons extend much shorter axons and project into the ventral region of the bulb

taste/olfaction

abnormal olfactory sensory neuron morphology ( J:122275 )

• most olfactory receptor neurons project to multiple more ventral glomeruli

• P2 olfactory receptor neurons extend much shorter axons and project into the ventral region of the bulb

growth/size/body

abnormal olfactory sensory neuron morphology ( J:122275 )

• most olfactory receptor neurons project to multiple more ventral glomeruli

• P2 olfactory receptor neurons extend much shorter axons and project into the ventral region of the bulb

Allelic Composition	Ebf2^tm1Reed/Ebf2⁺ Ebf3^tm1Reed/Ebf3⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ebf2^tm1Reed mutation (0 available); any Ebf2 mutation (30 available)
Ebf3^tm1Reed mutation (0 available); any Ebf3 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:88585 )

N	• unlike either Ebf2^tm1Reed and Ebf3^tm1Reed homozygotes, the olfactory bulb is of normal size and shape

abnormal olfactory neuron innervation pattern ( J:88585 )

• olfactory neurons fail to project to the dorsal olfactory bulb

Allelic Composition	Ebf2^tm1Reed/Ebf2⁺ Zfp423^tm1Reed/Zfp423^tm1Reed
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ebf2^tm1Reed mutation (0 available); any Ebf2 mutation (30 available)
Zfp423^tm1Reed mutation (0 available); any Zfp423 mutation (274 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal olfactory sensory neuron morphology ( J:122275 )

• olfactory receptor neuron axons fail to innervate the dorsal caudal region of the olfactory bulb

• extra glomeruli accumulate at the ventral surface

craniofacial

abnormal olfactory sensory neuron morphology ( J:122275 )

• olfactory receptor neuron axons fail to innervate the dorsal caudal region of the olfactory bulb

• extra glomeruli accumulate at the ventral surface

respiratory system

abnormal olfactory sensory neuron morphology ( J:122275 )

• olfactory receptor neuron axons fail to innervate the dorsal caudal region of the olfactory bulb

• extra glomeruli accumulate at the ventral surface

taste/olfaction

abnormal olfactory sensory neuron morphology ( J:122275 )

• olfactory receptor neuron axons fail to innervate the dorsal caudal region of the olfactory bulb

• extra glomeruli accumulate at the ventral surface

growth/size/body

abnormal olfactory sensory neuron morphology ( J:122275 )

• olfactory receptor neuron axons fail to innervate the dorsal caudal region of the olfactory bulb

• extra glomeruli accumulate at the ventral surface

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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