Phenotypes associated with this allele

• Allele Symbol: Npy5r^tm1Rpa
• Allele Name: targeted mutation 1, Richard D Palmiter
• Allele ID: MGI:3028279
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Npy5r^tm1Rpa/Npy5r^tm1Rpa	involves: 129S7/SvEvBrd	MGI:3640321
hm2	Npy5r^tm1Rpa/Npy5r^tm1Rpa	involves: 129S7/SvEvBrd * C57BL/6	MGI:3028330
cx3	Lep^ob/Lep^ob Npy5r^tm1Rpa/Npy5r^tm1Rpa	involves: 129S7/SvEvBrd * C57BL/6	MGI:3028331

Genotype
MGI:3640321

hm1

• Allelic Composition: Npy5r^tm1Rpa/Npy5r^tm1Rpa
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased retroperitoneal fat pad weight ( J:87424 )

• in response to chronic, central neuropeptide Y infusion, 6-7-month-old male homozygotes display a further increase in retroperitoneal fat pad mass to levels even higher than those found in NPY-treated wild-type males

growth/size/body

obese ( J:87424 )

• male homozygotes develop late-onset obesity probably secondary to hyperphagia

• in response to chronic, central neuropeptide Y infusion, 6-7-month-old male homozygotes display a comparable hyperphagic response and immediate development of an obesity syndrome similar to that observed in wild-type mice

homeostasis/metabolism

increased circulating corticosterone level ( J:87424 )

• in response to chronic, central neuropeptide Y infusion, 6-7-month-old male homozygotes display a comparable increase in plasma corticosterone levels relative to wild-type males

increased circulating insulin level ( J:87424 )

• in response to chronic, central neuropeptide Y infusion, 6-7-month-old male homozygotes display a further increase in plasma insulin to levels even higher than those found in NPY-treated wild-type males

increased circulating leptin level ( J:87424 )

• in response to chronic, central neuropeptide Y infusion, 6-7-month-old male homozygotes display a further increase in plasma leptin to levels even higher than those found in NPY-treated wild-type males

Genotype
MGI:3028330

hm2

• Allelic Composition: Npy5r^tm1Rpa/Npy5r^tm1Rpa
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

adipose tissue

increased total body fat amount ( J:87803 )

• older mice possess greater body fat deposits, particularly males

behavior/neurological

polyphagia ( J:87803 )

• older mice eat significantly more food, particularly males

• younger mice fed normally

growth/size/body

abnormal body weight ( J:87803 )

obese ( J:87803 )

• mild obesity develops with age, particularly among males

• younger animals grew normally

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:87803 )

N • metabolic rate unchanged

N • body temperature normal

liver/biliary system

hepatic steatosis ( J:87803 )

• older mice have fatty livers, particularly males

Genotype
MGI:3028331

cx3

• Allelic Composition: Lep^ob/Lep^ob; Npy5r^tm1Rpa/Npy5r^tm1Rpa
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

adipose tissue

increased total fat pad weight ( J:87803 )

• fat pad weight greatly increased over normal

behavior/neurological

polyphagia ( J:87803 )

• mice eat significantly more food

growth/size/body

abnormal body weight ( J:87803 )

obese ( J:87803 )

• weigh between 2 and 3 times normal