Npy5r^tm1Rpa
Targeted Allele Detail

Summary

• Symbol: Npy5r^tm1Rpa
• Name: neuropeptide Y receptor Y5; targeted mutation 1, Richard D Palmiter
• MGI ID: MGI:3028279
• Synonyms: Y5R-
• Gene: Npy5r Location: Chr8:67132617-67140746 bp, - strand Genetic Position: Chr8, 33.15 cM, cytoband B3-C2
• Alliance: Npy5r^tm1Rpa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87803
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 760bp from the coding region were replaced with lacZ and a neomycin resistance gene. The replaced sequence included the translation initiation codon and sequence coding for the first 5 transmembrane spanning domains. RT-PCR indicated that less than 10% of normal transcript levels were present and this was most likely the consequence of read-through from the neomycin resistance gene rather than wild-type transcript. (J:87803)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Npy5r Mutation: 26 strains or lines available

References

• Original: J:87803 Marsh DJ, et al., Role of the Y5 neuropeptide Y receptor in feeding and obesity. Nat Med. 1998 Jun;4(6):718-21
• All: 9 reference(s)