Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnai1tm1Drs mutation
(0 available);
any
Gnai1 mutation
(15 available)
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behavior/neurological
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• hippocampal long term memory was perturbed
• spatial memory was normal as determined by a Morris water maze test
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• cued auditory training and memory extinction were normal
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• partial loss of memory at 24 hours
• complete loss of memory by 8 days
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• memory defects in contextual training
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• object recognition was compromised
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nervous system
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• early phase LTP unaffected
• late phase LTP more persistent
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Allelic Composition |
Gnai1tm1Drs/Gnai1+
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Genetic Background |
Not Specified |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnai1tm1Drs mutation
(0 available);
any
Gnai1 mutation
(15 available)
|
|
|
behavior/neurological
|
• hippocampal long term memory was perturbed
• spatial memory was normal as determined by a Morris water maze test
|
|
• cued auditory training and memory extinction were normal
|
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• partial memory loss at 24 hours
|
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• object recognition was compromised
|
nervous system
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• early phase LTP unaffected
• late phase LTP persistence intermediate between homozygotes and wild-type mice
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnai1tm1Drs mutation
(0 available);
any
Gnai1 mutation
(15 available)
Gnai3tm1Lbi mutation
(1 available);
any
Gnai3 mutation
(28 available)
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Rib and sternum defects in mice with mutations of Gnai1, Gnai2, and/or Gnai3
immune system
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• decrease in IL-10 production from peritoneal monocytes after in vitro lipopolysaccharide-induction
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• increase in TNFa production from spleen monocytes after in vitro lipopolysaccharide-induction
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homeostasis/metabolism
skeleton
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• rib fusions are more frequent and severe compared to mice homozygous for Gnai3tm1Lbi alone
• rib fusions frequently involve both true and false ribs
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• not noticeably more severe than in ice homozygous for Gnai3tm1Lbi alone
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnai1tm1Drs mutation
(0 available);
any
Gnai1 mutation
(15 available)
Gnai3tm1Lbi mutation
(1 available);
any
Gnai3 mutation
(28 available)
|
|
|
Rib and sternum defects in mice with mutations of Gnai1, Gnai2, and/or Gnai3
skeleton
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• rib fusions are more frequent and severe compared to mice homozygous for Gnai3tm1Lbi alone
• rib fusions frequently involve both true and false ribs
|
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• not noticeably more severe than in mice homozygous for Gnai3tm1Lbi alone
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnai1tm1Drs mutation
(0 available);
any
Gnai1 mutation
(15 available)
Gnai2tm1Lbi mutation
(1 available);
any
Gnai2 mutation
(54 available)
|
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Rib and sternum defects in mice with mutations of Gnai1, Gnai2, and/or Gnai3
skeleton
N |
• no rib fusions are detected
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• one mouse has the eighth rib ectopically attached to the sternum
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