Phenotypes associated with this allele

• Allele Symbol: Efnb3^tm1.1Henk
• Allele Name: targeted mutation 1.1, Mark Henkemeyer
• Allele ID: MGI:3026702
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Efnb3^tm1.1Henk/Efnb3^tm1.1Henk	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)	MGI:3026745
hm2	Efnb3^tm1.1Henk/Efnb3^tm1.1Henk	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:3851496
cx3	Efnb3^tm1.1Henk/Efnb3^tm1.1Henk Ephb2^tm1Jf/Ephb2^tm1Jf Lnx1^tm1Henk/Lnx1^tm1Henk	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:8228084

Genotype
MGI:3026745

hm1

• Allelic Composition: Efnb3^tm1.1Henk/Efnb3^tm1.1Henk
• Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:87497 )

• mice retain Eph-ephrin forward signaling and do not exhibit a hopping gait

Genotype
MGI:3851496

hm2

• Allelic Composition: Efnb3^tm1.1Henk/Efnb3^tm1.1Henk
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

nervous system

abnormal axon pruning ( J:150550 )

• mossy fiber pruning is defective

abnormal axon morphology ( J:150550 )

• infra-pyramidal bundle (IPB) axons are longer than in wild-type mice

cellular

abnormal axon pruning ( J:150550 )

• mossy fiber pruning is defective

Genotype
MGI:8228084

cx3

• Allelic Composition: Efnb3^tm1.1Henk/Efnb3^tm1.1Henk; Ephb2^tm1Jf/Ephb2^tm1Jf; Lnx1^tm1Henk/Lnx1^tm1Henk
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

nervous system

abnormal hippocampal mossy fiber morphology ( J:267455 )

• disruption of mossy fiber axon terminal targeting