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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Efnb3tm1.1Henk
targeted mutation 1.1, Mark Henkemeyer
MGI:3026702
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Efnb3tm1.1Henk/Efnb3tm1.1Henk either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1) MGI:3026745
hm2
 		Efnb3tm1.1Henk/Efnb3tm1.1Henk involves: 129S1/Sv * 129X1/SvJ * CD-1 MGI:3851496


Genotype
MGI:3026745
hm1
Allelic
Composition		 Efnb3tm1.1Henk/Efnb3tm1.1Henk
Genetic
Background		 either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb3tm1.1Henk mutation (0 available); any Efnb3 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:87497 )
• mice retain Eph-ephrin forward signaling and do not exhibit a hopping gait




Genotype
MGI:3851496
hm2
Allelic
Composition		 Efnb3tm1.1Henk/Efnb3tm1.1Henk
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb3tm1.1Henk mutation (0 available); any Efnb3 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon pruning ( J:150550 )
• mossy fiber pruning is defective
abnormal axon morphology ( J:150550 )
• infra-pyramidal bundle (IPB) axons are longer than in wild-type mice

cellular
abnormal axon pruning ( J:150550 )
• mossy fiber pruning is defective




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory