Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr5tm1Kuz mutation
(2 available);
any
Ccr5 mutation
(29 available)
Tg(CAG-EGFP)1Osb mutation
(8 available)
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neoplasm
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• 40.2 metastic colonies compared to 70.6 colonies for controls 14 days after injecting B16-F10 melanoma cells
• fewer metastatic tumors 14 days after injecting irradiated mice with melanoma cells
• injection of wild type lung stromal cells enhanced metastasis relative to injection of mutant stromal cells
• improved survival
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cryaa2J mutation
(0 available);
any
Cryaa mutation
(14 available)
Tg(CAG-EGFP)1Osb mutation
(8 available)
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vision/eye
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• peripheral fiber cells of E16.5 lenses contain degenerated mitochondria with severe loss of matrix and cristae or with vacuoles
• severely disrupted actin filaments are seen in contact regions between anterior epithelial cells and posterior fiber cells in lenses at E16.5
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• altered epithelial cells and degenerated fiber cells are seen in lenses; epithelial cells are detached from or aggregated beneath the lense capsule and posterior fiber cells are only partially elongated
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• epithelium is severely altered; epithelial layer contains irregularly shaped cells and vesicle-like cellular structures, thus lacking polarized monolayer of cuboidal epithelial cells morphology seen in wild-type
• severely disrupted actin filaments are seen in contact regions between anterior epithelial cells and posterior fiber cells in lenses at E16.5
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
CryaaL1N mutation
(0 available);
any
Cryaa mutation
(14 available)
Tg(CAG-EGFP)1Osb mutation
(8 available)
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vision/eye
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• histology shows no obvious changes in lens epithelial and fiber cells at weaning age
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• analysis shows that mutant lenses contain a greater amount of water-insoluble crystallin proteins, likely correlating with the nuclear cataracts observed in mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-EGFP)1Osb mutation
(8 available)
Tg(Rho)1Wbae mutation
(0 available)
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nervous system
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• double mutants exhibit the same level of retinal degeneration as is observed in hemizygous Tg(Rho)1Wbae mice
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vision/eye
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• double mutants exhibit the same level of retinal degeneration as is observed in hemizygous Tg(Rho)1Wbae mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-EGFP)1Osb mutation
(8 available)
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mortality/aging
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• homozygous transgenic mice die in the embryonic stage, putatively due to integration site effect
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-EGFP)1Osb mutation
(8 available)
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normal phenotype
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• mice are viable and show no functional or morphological abnormalities of the retina
(J:87298)
• all tissues, except for erytrhocytes and hair, are green under excitation light
(J:87415)
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Analysis Tools