Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ubr2tm1Ytkw mutation
(0 available);
any
Ubr2 mutation
(59 available)
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mortality/aging
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• very few homozygotes of either sex produced
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reproductive system
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• testis degeneration not as severe as on the mixed background with C57BL/6
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endocrine/exocrine glands
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• testis degeneration not as severe as on the mixed background with C57BL/6
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ubr2tm1Ytkw mutation
(0 available);
any
Ubr2 mutation
(59 available)
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mortality/aging
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• lower than expected numbers of homozygous females born
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growth/size/body
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• rare surviving females were growth retarded by 2 months of age
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reproductive system
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• testes degeneration starts around 3 weeks and continues past 8 weeks
• at 8 weeks, testes are about 1/4 normal weight
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• epididymal sperm count averaged about 30% lower
• low levels of sperm in the epididymis at 8 weeks and that sperm was abnormal
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• spermatogenesis stops at or before the pachytene stage of prophase I
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• rare surviving females showed reduced fertility
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• males were infertile but in early generations and later phenotype ameliorated somewhat
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embryo
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• 6 out of 13 E7.5 female embryos were growth arrested or deformed
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• increased apoptosis in E9.5 and E11.5 growth arrested female embryos
• no abnormality in apoptosis if growth was normal
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• increased apoptosis in E9.5 and E11.5 growth arrested female embryos
• no abnormality in apoptosis if growth was normal
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endocrine/exocrine glands
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• testes degeneration starts around 3 weeks and continues past 8 weeks
• at 8 weeks, testes are about 1/4 normal weight
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cellular
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• epididymal sperm count averaged about 30% lower
• low levels of sperm in the epididymis at 8 weeks and that sperm was abnormal
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• increased apoptosis in E9.5 and E11.5 growth arrested female embryos
• no abnormality in apoptosis if growth was normal
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ubr2tm1Ytkw mutation
(0 available);
any
Ubr2 mutation
(59 available)
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mortality/aging
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• lower than expected numbers (9) of homozygous females born
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reproductive system
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• testes degeneration not as severe as on a mixed background with C57BL/6
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endocrine/exocrine glands
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• testes degeneration not as severe as on a mixed background with C57BL/6
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ubr1tm1Avar mutation
(0 available);
any
Ubr1 mutation
(61 available)
Ubr2tm1Ytkw mutation
(0 available);
any
Ubr2 mutation
(59 available)
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Abnormal development of the central nervous system in Ubr1tm1Avar/Ubr1tm1Avar Ubr2tm1Ytkw/Ubr2tm1Ytkw embryos
mortality/aging
growth/size/body
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• embryos are smaller at E10.5 but not at earlier stages
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embryo
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• by E10.5, blood vessels in the yolk sac are thinner and less branched
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• growth ceases at around E10.5
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• embryos are smaller at E10.5 but not at earlier stages
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• neuroepithelium at E10.5 is composed of 3 layers (VZ, SVZ, and mantle) instead of two (VZ and mantle) as in wild-type
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• neuroepithelium at E10.5 is thin, with greater severity in the forebrain than in the spinal cord
• neuroepithelial structures do not increase in thickness after E10.5, in contrast to control embryos
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• neural tubes are normal at E10.5 but by E11.5 become kinked
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• appears pale by E10.5 but not at earlier stages
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• staining for Pecam-1 at E10.5 shows that growth, remodeling, and branching of both small and large vessels is impaired
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nervous system
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• exhibit increased amounts apoptosis throughout the neural tubes at E10.5
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• reduction in proliferation and precocious migration and differentiation of neural progenitor cells
• decrease in the levels of S-phase neural precursor cells throughout the anteroposterior axis at E10.5, indicating impaired proliferation in the ventricular zone (VZ)
• higher numbers of mitotic neural precursors are present in the VZ of the forebrain at E10.5 and the distribution of mitotic cells is disorganized
• many mitotic cells appear to be between the interphase and prophase (instead of prophase or prometaphase as in wild-type), suggesting an arrest
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• neuroepithelium at E10.5 is composed of 3 layers (VZ, SVZ, and mantle) instead of two (VZ and mantle) as in wild-type
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• neuroepithelium at E10.5 is thin, with greater severity in the forebrain than in the spinal cord
• neuroepithelial structures do not increase in thickness after E10.5, in contrast to control embryos
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• neural tubes are normal at E10.5 but by E11.5 become kinked
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• by E11.5, forebrain morphology is distorted, with serpentine, thin, often disjointed neuroepithelial layers of varying thickness
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cardiovascular system
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• larger vessels such as the intracranial artery are thin an poorly developed at E10.5
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• by E10.5, blood vessels in the yolk sac are thinner and less branched
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• exhibit a large space between the heart and pericardium at E10.5, consistent with the accumulation of pericardial fluid
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• trabeculations are thinner and less abundant
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• disorganization of the myocardial wall at E10.5
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• development of the atria and ventricles is arrested by E10.5
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• development of the atria is arrested by E10.5
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• interatrial septa formation is not observed by E10.5
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• development of the ventricles is arrested by E10.5
• variable levels of ventricular atrophy
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• interventricular septa formation is not observed by E10.5
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• develop local hemorrhages by E10.5 (but not at E9.5)
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muscle
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• trabeculations are thinner and less abundant
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• disorganization of the myocardial wall at E10.5
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homeostasis/metabolism
cellular
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• exhibit increased amounts apoptosis throughout the neural tubes at E10.5
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• reduction in proliferation and precocious migration and differentiation of neural progenitor cells
• decrease in the levels of S-phase neural precursor cells throughout the anteroposterior axis at E10.5, indicating impaired proliferation in the ventricular zone (VZ)
• higher numbers of mitotic neural precursors are present in the VZ of the forebrain at E10.5 and the distribution of mitotic cells is disorganized
• many mitotic cells appear to be between the interphase and prophase (instead of prophase or prometaphase as in wild-type), suggesting an arrest
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Analysis Tools