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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pmaip1tm1Ast
targeted mutation 1, Andreas Strasser
MGI:2681649
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pmaip1tm1Ast/Pmaip1tm1Ast C57BL/6-Pmaip1tm1Ast MGI:2681656
hm2
 		Pmaip1tm1Ast/Pmaip1tm1Ast involves: C57BL/6 MGI:3815011
cx3
 		Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Pmaip1tm1Ast/Pmaip1tm1Ast 		involves: 129S1/Sv * C57BL/6 MGI:3720170


Genotype
MGI:2681656
hm1
Allelic
Composition		 Pmaip1tm1Ast/Pmaip1tm1Ast
Genetic
Background		 C57BL/6-Pmaip1tm1Ast
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pmaip1tm1Ast mutation (1 available); any Pmaip1 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased sensitivity to induced cell death ( J:86466 )
• modest but significant resistance to etoposide induced apoptosis in mouse embryo fibroblasts but not in thymocytes and other lymphocytes

immune system
abnormal NK cell morphology ( J:123409 )
• following expansion in culture, NK cells survive IL-15 withdrawal better than wild-type cells

hematopoietic system
abnormal NK cell morphology ( J:123409 )
• following expansion in culture, NK cells survive IL-15 withdrawal better than wild-type cells




Genotype
MGI:3815011
hm2
Allelic
Composition		 Pmaip1tm1Ast/Pmaip1tm1Ast
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pmaip1tm1Ast mutation (1 available); any Pmaip1 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:132819 )
N
• no abnormalities are detected in T cell numbers after HSV-1 infection

nervous system
nervous system phenotype ( J:127640 )
N
• unlike mice homozygous for Bbc3tm1Ast neuron sensitivity to oxidative stressor induced apoptosis is similar to controls




Genotype
MGI:3720170
cx3
Allelic
Composition		 Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Pmaip1tm1Ast/Pmaip1tm1Ast
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm1.1Ast mutation (4 available); any Bcl2l11 mutation (32 available)
Pmaip1tm1Ast mutation (1 available); any Pmaip1 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal NK cell morphology ( J:123409 )
• following expansion in culture, NK cells survive IL-15 withdrawal better than wild-type cells and Bcl2l11tm1.1Ast homozygotes

hematopoietic system
abnormal NK cell morphology ( J:123409 )
• following expansion in culture, NK cells survive IL-15 withdrawal better than wild-type cells and Bcl2l11tm1.1Ast homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory