All Phenotypes Nxf1<Mvb1> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nxf1^Mvb1
modifier of vibrator 1
MGI:2680965

Summary

10 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nxf1^Mvb1/Nxf1^Mvb1	involves: C3H/HeJ * C57BL/6J * CAST/Ei	MGI:3722670
cx2	Nxf1^Mvb1/Nxf1^Mvb1 Pitpna^vb/Pitpna^vb	involves: C3HeB/Fe * C57BL/6J * CAST/Ei * DBA/2J	MGI:3719467
cx3	Eya1^bor/Eya1^bor Nxf1^Mvb1/Nxf1⁺	involves: C3HeB/FeJ * C57BL/6J * CAST/Ei	MGI:3719482
cx4	Eya1^bor/Eya1^bor Nxf1^Mvb1/Nxf1^Mvb1	involves: C3HeB/FeJ * C57BL/6J * CAST/Ei	MGI:3719480
cx5	Ap3d1^mh-2J/Ap3d1^mh-2J Nxf1^Mvb1/Nxf1^Mvb1	involves: C3H/HeJ * C57BL/6	MGI:3848524
cx6	Atcay^ji-hes/Atcay^ji-hes Nxf1^Mvb1/Nxf1^Mvb1	involves: C3H/HeJ * C57BL/6	MGI:3848526
cx7	Nxf1^Mvb1/Nxf1^Mvb1 Usp14^ax-J/Usp14^ax-J	involves: C57BL/6	MGI:3848536
cx8	Nxf1^em1Haml/Nxf1^Mvb1 Pitpna^vb/Pitpna^vb	involves: C57BL/6 * DBA/2J	MGI:5629975
cx9	Nxf1^Mvb1/Nxf1^Mvb1 Pitpna^vb/Pitpna^vb	involves: C57BL/6J * CAST/Ei * DBA/2J	MGI:3722644
cx10	Nxf1^Mvb1/Nxf1⁺ Pitpna^vb/Pitpna^vb	involves: C57BL/6J * CAST/Ei * DBA/2J	MGI:3722646

Allelic Composition	Nxf1^Mvb1/Nxf1^Mvb1
Genetic Background	involves: C3H/HeJ * C57BL/6J * CAST/Ei

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nxf1^Mvb1 mutation (1 available); any Nxf1 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:86371 )

N	• more Nxf1^Mvb1-CAST/Ei homozygotes are generated from a cross betwen Eya1^bor and Nxf1^Mvb1-CAST/Ei mice than non-Nxf1^Mvb1-CAST/Ei homozygotes

Allelic Composition	Nxf1^Mvb1/Nxf1^Mvb1 Pitpna^vb/Pitpna^vb
Genetic Background	involves: C3HeB/Fe * C57BL/6J * CAST/Ei * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nxf1^Mvb1 mutation (1 available); any Nxf1 mutation (35 available)
Pitpna^vb mutation (1 available); any Pitpna mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

tremors ( J:40754 )

• only mild tremors are observed

nervous system

nervous system phenotype ( J:40754 )

N	• no abnormalities are detected in the brains stem or spinal cord

Allelic Composition	Eya1^bor/Eya1^bor Nxf1^Mvb1/Nxf1⁺
Genetic Background	involves: C3HeB/FeJ * C57BL/6J * CAST/Ei

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eya1^bor mutation (2 available); any Eya1 mutation (54 available)
Nxf1^Mvb1 mutation (1 available); any Nxf1 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

increased or absent threshold for auditory brainstem response ( J:86371 )

• the auditory brainstem threshold is increased compared to wild-type mice but intermediate between Eya1^bor Nxf1^{Mvb1-C57BL/6J} and Eya1^bor Nxf1^Mvb1-CAST/Ei homozygotes

Allelic Composition	Eya1^bor/Eya1^bor Nxf1^Mvb1/Nxf1^Mvb1
Genetic Background	involves: C3HeB/FeJ * C57BL/6J * CAST/Ei

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

head bobbing ( J:86371 )

• mice exhibit less noticeable head bobbing compared to Eya1^bor Nxf1^{Mvb1-C57BL/6J} homozygotes

circling ( J:86371 )

• mice exhibit less noticeable circling compared to Eya1^bor Nxf1^{Mvb1-C57BL/6J} homozygotes

hearing/vestibular/ear

increased or absent threshold for auditory brainstem response ( J:86371 )

• the auditory brainstem threshold is increased compared to wild-type mice but less than that of Eya1^bor Nxf1^{Mvb1-C57BL/6J} homozygotes

nervous system

abnormal cochlear ganglion morphology ( J:86371 )

• 6 of 12 mice have a loss of spiral ganglion cells in the apical turn of the cochlea

• 3 of 12 mice have more severe phenotypes

renal/urinary system

renal/urinary system phenotype ( J:86371 )

N	• mice do not exhibit kidney defects or associated mortality as in Eya1^bor homozygotes

Allelic Composition	Ap3d1^mh-2J/Ap3d1^mh-2J Nxf1^Mvb1/Nxf1^Mvb1
Genetic Background	involves: C3H/HeJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ap3d1^mh-2J mutation (1 available); any Ap3d1 mutation (79 available)
Nxf1^Mvb1 mutation (1 available); any Nxf1 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Ap3d1^mh-2J/Ap3d1^mh-2J coat color dilution is attenuated in Ap3d1^mh-2J/Ap3d1^mh-2J Nxf1^Mvb1/Nxf1^Mvb1 mice

pigmentation

abnormal coat/hair pigmentation ( J:149430 )

• normalization of pigmentation relative to Ap3d1^mh-2J single homozygotes

behavior/neurological

tremors ( J:149430 )

• reduced tremors relative to Ap3d1^mh-2J single homozygotes

integument

abnormal coat/hair pigmentation ( J:149430 )

• normalization of pigmentation relative to Ap3d1^mh-2J single homozygotes

Allelic Composition	Atcay^ji-hes/Atcay^ji-hes Nxf1^Mvb1/Nxf1^Mvb1
Genetic Background	involves: C3H/HeJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atcay^ji-hes mutation (1 available); any Atcay mutation (27 available)
Nxf1^Mvb1 mutation (1 available); any Nxf1 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

ataxia ( J:149430 )

• reduced ataxia relative to Ap3d1^mh-2J single homozygotes

abnormal locomotor activation ( J:149430 )

• elimination of the tendency to jump out of open fields in behavior tests displayed by Ap3d1^mh-2J single homozygotes

Allelic Composition	Nxf1^Mvb1/Nxf1^Mvb1 Usp14^ax-J/Usp14^ax-J
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nxf1^Mvb1 mutation (1 available); any Nxf1 mutation (35 available)
Usp14^ax-J mutation (1 available); any Usp14 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

tremors ( J:149430 )

• reduced amplitude of tremors relative to those of Usp14^ax-J singlle homozygotes

Allelic Composition	Nxf1^em1Haml/Nxf1^Mvb1 Pitpna^vb/Pitpna^vb
Genetic Background	involves: C57BL/6 * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nxf1^em1Haml mutation (1 available); any Nxf1 mutation (35 available)
Nxf1^Mvb1 mutation (1 available); any Nxf1 mutation (35 available)
Pitpna^vb mutation (1 available); any Pitpna mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

abnormal survival ( J:219914 )

• improved survival compared with Nxf1^{Mvb1-C57BL/6J}/Nxf1^Mvb1-CAST/Ei Pitpna^vb/Pitpna^vb mice

behavior/neurological

tremors ( J:219914 )

• reduced tremor score compared with Nxf1^{Mvb1-C57BL/6J}/Nxf1^Mvb1-CAST/Ei Pitpna^vb/Pitpna^vb mice

Allelic Composition	Nxf1^Mvb1/Nxf1^Mvb1 Pitpna^vb/Pitpna^vb
Genetic Background	involves: C57BL/6J * CAST/Ei * DBA/2J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:86371 )

N	• lethality observed in Pitpna^vb mice is suppressed with mice living past 750 days compared to less than 100 days in Pitna^vb homozygotes

nervous system

abnormal neuron morphology ( J:86371 )

• fewer neurons with pathologies were observed than in Pitpna^vb/Pitpna^vb Nxf1^Mvb1-CAST/Ei/Nxf1^{Mvb1-C57BL/6J} mice

Allelic Composition	Nxf1^Mvb1/Nxf1⁺ Pitpna^vb/Pitpna^vb
Genetic Background	involves: C57BL/6J * CAST/Ei * DBA/2J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:86371 )

• lethality observed in Pitpna^vb mice is suppressed with mice living past 500 days compared to less than 100 days in Pitna^vb homozygotes and more than 750 days in Pitna^vb Nxf1^mvb1-CAST/Ei homozygotes

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