Nxf1^Mvb1
Spontaneous Allele Detail

Summary

• Symbol: Nxf1^Mvb1
• Name: nuclear RNA export factor 1; modifier of vibrator 1
• MGI ID: MGI:2680965
• Gene: Nxf1 Location: Chr19:8734467-8748274 bp, + strand Genetic Position: Chr19, 5.5 cM, cytoband A
• Alliance: Nxf1^Mvb1 page

Mutation origin

• Strain of Origin: CAST/Ei

Mutation description

• Allele Type: Spontaneous
• Mutation: Nucleotide substitutions
• Mutation details: This allele codes for a pro at amino acid residue 48 and for a gly at amino acid residue 610. Carriers of this allele suppress disruptions at other gene loci caused specifically by intron insertions of IAP elements in the sense orientation only. This effect results from a quantitative shift in RNA isoforms from high molecular weight disrupted transcripts to correctly processed wild-type transcripts. Crosses with several alleles (Pitpna^vb, Eya1^bor, A^iy, Axin1^Fu, Dab1^scm, Hr^hr, Myo5a^d, and a) revealed that this allele can only suppress sense-orientation insertions (Pitpna^vb and Eya1^bor), including at least some class D elements, such as IAPS but not class C insertions, such as MLVs. (J:86371)
• Inheritance: Not Specified

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nxf1 Mutation: 35 strains or lines available

References

• Original: J:40754 Hamilton BA, et al., The vibrator mutation causes neurodegeneration via reduced expression of PITP alpha: positional complementation cloning and extragenic suppression. Neuron. 1997 May;18(5):711-22
• All: 4 reference(s)