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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ticam1Lps2
lipopolysaccharide 2
MGI:2679794
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ticam1Lps2/Ticam1Lps2 C57BL/6J-Ticam1Lps2 MGI:5000268
hm2
Ticam1Lps2/Ticam1Lps2 C57BL/6J-Ticam1Lps2/J MGI:5520919
hm3
Ticam1Lps2/Ticam1Lps2 involves: C57BL/6 MGI:2680622
cx4
Ptpn6m1Btlr/Ptpn6m1Btlr
Ticam1Lps2/Ticam1Lps2
C57BL/6J-Ptpn6m1Btlr Ticam1Lps2 MGI:3822471
cx5
Ticam1Lps2/Ticam1Lps2
Myd88tm1Aki/Myd88tm1Aki
involves: 129P2/OlaHsd * C57BL/6 MGI:2680623
cx6
Irak4m1Btlr/Irak4m1Btlr
Ticam1Lps2/Ticam1Lps2
involves: C57BL/6J MGI:5437490


Genotype
MGI:5000268
hm1
Allelic
Composition
Ticam1Lps2/Ticam1Lps2
Genetic
Background
C57BL/6J-Ticam1Lps2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ticam1Lps2 mutation (2 available); any Ticam1 mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Decreased susceptibility to induced colitis in Ticam1Lps2/Ticam1Lps2 mice

vision/eye
• neuronal differentiation of precursors
• more proliferating cells in the retina at 6 days of age

nervous system
N
• no neurological defects after cerebral ischemia/reperfusion (as with controls)
• infarct size similar to controls

digestive/alimentary system
• flagellin stimulated primary intestinal epithelial cells display dramatically suppressed production of keratinocyte-derived cytokine, macrophage inflammatory protein 3 alpha, and IL-6
• significantly improved survival from experimental colitis induced with dextran sodium sulfate and flagellin treatment
• much less histological damage to colon epithelium in induced colitis
• recovery from colitis is improved

immune system
N
• flagellin induction of IFN-beta production is unaffected
• significantly improved survival from experimental colitis induced with dextran sodium sulfate and flagellin treatment
• much less histological damage to colon epithelium in induced colitis
• recovery from colitis is improved
• ethanol containing diet fails to cause a significant increase in serum TNF as occurs in controls
• flagellin stimulated primary intestinal epithelial cells display dramatically suppressed production of keratinocyte-derived cytokine and macrophage inflammatory protein 3 alpha
• IL-1beta strongly induces keratinocyte-derived cytokine production
• flagellin stimulated primary intestinal epithelial cells display dramatically suppressed production

growth/size/body
• resistant to weight loss in experimental colitis

liver/biliary system
• fail to develop ethanol induced liver steatosis as occurs in controls

homeostasis/metabolism
• ethanol containing diet fails to cause a significant increase in serum TNF as occurs in controls




Genotype
MGI:5520919
hm2
Allelic
Composition
Ticam1Lps2/Ticam1Lps2
Genetic
Background
C57BL/6J-Ticam1Lps2/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ticam1Lps2 mutation (2 available); any Ticam1 mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• rMA15-SARS-CoV-infected mice show increased recruitment of neutrophils in the lungs at 4 dpi, however by 6 dpi, this is no longer different
• mice show more plasmacytoid dendritic cells in the lungs at 6 dpi, but not 4 dpi, with rMA15-SARS-CoV
• however, no differences from wild-type are seen in populations of eosinophils, monocyte-derived dendritic cells or in CD11b+ dendritic cell populations, or lymphocytes after rMA15-SARS-CoV infection
• mice show fewer CD8+ T cells in the lungs at 6 dpi, but not 4 dpi, with rMA15-SARS-CoV
• however, no differences in the number of CD4+ T cells are seen
• mice show more alveolar macrophages in the lungs at 6 dpi, but not 4 dpi, with rMA15-SARS-CoV
• mice show more Ly6C high inflammatory monocytes following rMA15-SARS-CoV infection at 4 dpi but not on 6 dpi
• mice show similar numbers of Ly6C low monocytes as wild-type mice following rMA15-SARS-CoV infection at 4 dpi but lower numbers at 6 dpi
• levels of chemokines that are chemotactic for neutrophil recruitment (CXCL1, CXCL2, CXCL3) are lower on 2 dpi with rMA15-SARS-CoV but are higher on 4 dpi
• rMA15-SARS-CoV-infected mice show increased IFN-beta levels in lung homogenates on 2 and 4 dpi
• mice infected intranasally with the mouse-adapted rMA15-SARS-CoV show greater weight loss and continue to lose weight when wild-type mice are recovering, increased viral loads in the lungs and detectable virus at day 6 post-infection when wild-type mice clear the virus
• mice show greater susceptibility to SARS-CoV infection than Tlr3tm1Flv homozygotes
• rMA15-SARS-CoV-infected mice show more viral antigen in the lungs; more viral antigen is seen in the parenchyma of the lungs but not in the large airways when compared to wild-type mice
• in the large airways, infected cells in the large airways are ciliated airway epithelial cells and are type II pneumocytes in the alveolar spaces

mortality/aging

homeostasis/metabolism
• levels of chemokines that are chemotactic for neutrophil recruitment (CXCL1, CXCL2, CXCL3) are lower on 2 dpi with rMA15-SARS-CoV but are higher on 4 dpi
• following induction of necrotizing enterocolitis, mice exhibit preservation of the small intestinal mucosa compared with wild-type mice

respiratory system
• rMA15-SARS-CoV-infected mice show severe hemorrhage in the lungs at day 6 post-infection
• rMA15-SARS-CoV-infected mice show higher levels of enhanced and infection-associated airway obstruction
• rMA15-SARS-CoV-infected mice show higher levels of enhanced pause indicating airway hyperresponsiveness
• rMA15-SARS-CoV-infected mice show higher midtidal expiratory flow

cardiovascular system
• rMA15-SARS-CoV-infected mice show severe hemorrhage in the lungs at day 6 post-infection

hematopoietic system
• rMA15-SARS-CoV-infected mice show increased recruitment of neutrophils in the lungs at 4 dpi, however by 6 dpi, this is no longer different
• mice show more plasmacytoid dendritic cells in the lungs at 6 dpi, but not 4 dpi, with rMA15-SARS-CoV
• however, no differences from wild-type are seen in populations of eosinophils, monocyte-derived dendritic cells or in CD11b+ dendritic cell populations, or lymphocytes after rMA15-SARS-CoV infection
• mice show fewer CD8+ T cells in the lungs at 6 dpi, but not 4 dpi, with rMA15-SARS-CoV
• however, no differences in the number of CD4+ T cells are seen
• mice show more alveolar macrophages in the lungs at 6 dpi, but not 4 dpi, with rMA15-SARS-CoV
• mice show more Ly6C high inflammatory monocytes following rMA15-SARS-CoV infection at 4 dpi but not on 6 dpi
• mice show similar numbers of Ly6C low monocytes as wild-type mice following rMA15-SARS-CoV infection at 4 dpi but lower numbers at 6 dpi




Genotype
MGI:2680622
hm3
Allelic
Composition
Ticam1Lps2/Ticam1Lps2
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ticam1Lps2 mutation (2 available); any Ticam1 mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• responses of macrophages to LPS are reduced, with decreased or abolished apoptosis, nitric oxide production, TNF production, and type I interferon production
• greatly reduced apoptosis of Tlr3 and Tlr4 stimulated macrophage (J:92674)
• type I inferferon activity is undetected in culture medium of LPS- or dsRNA-activated macrophages
• no production of type I interferons in response to mouse cytomegalovirus
• LPS-induced nitric oxide production by macrophages is abolished
• 10,000 fold reduction in the TNF alpha response to lipopolysaccharide
• cytokine secretion induced by naked polyI:C is severely impaired by 5- to 10-fold
• however, secretion induced by transfected polyI:C is unaffected
• TNF production in response to LPS, synthetic lipid A, and dsRNA is decreased or abolished
• though some mice become ill and die after intraperitoneal lipopolysaccharide (LPS) injection, the survival rate is significantly greater than that of wild-type
• diminished response to lipopolysaccharide (J:86521)
• 10,000 fold reduction in the TNF alpha response to lipopolysaccharide (J:86521)
• considerable protection against Yersinia enterocolitica induced apoptosis of macrophage (J:92674)
• mice are more susceptible to cytomegalovirus infection, with increased lethality and higher viral titers than wild-type mice
• macrophage cultures infected with Vaccinia virus show higher viral titers than control macrophages

homeostasis/metabolism
• LPS-induced nitric oxide production by macrophages is abolished
• 10,000 fold reduction in the TNF alpha response to lipopolysaccharide

cellular
• greatly reduced apoptosis of Tlr3 and Tlr4 stimulated macrophage (J:92674)

hematopoietic system
• responses of macrophages to LPS are reduced, with decreased or abolished apoptosis, nitric oxide production, TNF production, and type I interferon production
• greatly reduced apoptosis of Tlr3 and Tlr4 stimulated macrophage (J:92674)
• type I inferferon activity is undetected in culture medium of LPS- or dsRNA-activated macrophages
• no production of type I interferons in response to mouse cytomegalovirus
• LPS-induced nitric oxide production by macrophages is abolished




Genotype
MGI:3822471
cx4
Allelic
Composition
Ptpn6m1Btlr/Ptpn6m1Btlr
Ticam1Lps2/Ticam1Lps2
Genetic
Background
C57BL/6J-Ptpn6m1Btlr Ticam1Lps2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptpn6m1Btlr mutation (1 available); any Ptpn6 mutation (34 available)
Ticam1Lps2 mutation (2 available); any Ticam1 mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• Ticam1 deficiency does not prevent the plantar inflammation that is a phenotypic characteristic for Ptpn6m1Btlr homozygotes




Genotype
MGI:2680623
cx5
Allelic
Composition
Ticam1Lps2/Ticam1Lps2
Myd88tm1Aki/Myd88tm1Aki
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myd88tm1Aki mutation (9 available); any Myd88 mutation (43 available)
Ticam1Lps2 mutation (2 available); any Ticam1 mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• no response to LPS in vitro
• TNF production by macrophages in response to LPS is abolished

hematopoietic system
• no response to LPS in vitro




Genotype
MGI:5437490
cx6
Allelic
Composition
Irak4m1Btlr/Irak4m1Btlr
Ticam1Lps2/Ticam1Lps2
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irak4m1Btlr mutation (2 available); any Irak4 mutation (19 available)
Ticam1Lps2 mutation (2 available); any Ticam1 mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• peritoneal macrophage fail to exhibit a TLR-induced TNFalpha response





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last database update
01/24/2023
MGI 6.22
The Jackson Laboratory