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Chemically induced Allele Detail
Symbol: Irak4m1Btlr
Name: interleukin-1 receptor-associated kinase 4; mutation 1, Bruce Beutler
MGI ID: MGI:3774129
Synonyms: otiose
Gene: Irak4  Location: Chr15:94441495-94466198 bp, + strand  Genetic Position: Chr15, 48.55 cM, cytoband F1
Alliance: Irak4m1Btlr page
Strain of Origin:  C57BL/6J
Project Collection: Beutler Mutagenetix
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
Mutation detailsThe otiose mutation, which was identified in an ENU mutagenesis screen for mutants with altered responses to Toll-like receptor (TLR) ligands, corresponds to a T to C transition at nucleotide position 1095 of the gene, in exon 9 of 12 total exons. No immunoreactive protein is detected by western blot analysis of mutant macrophages, and immunoprecipitated protein from mutant macrophages exhibits no kinase activity in vitro. (J:86521, J:133271)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Irak4 Mutation:  19 strains or lines available
Original:  J:133271 Berger M, et al., Otiose is an allele of Irak4 and has TLR-signaling defects. MGI Direct Data Submission. 2008;
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MGI 6.22
The Jackson Laboratory