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Caption Ticam1 deficiency confers protective effects against dextran sulfate sodium (DSS)-induced colitis and flagellin-mediated exacerbation of DSS-induced colitis. Flagellin-exacerbated DSS-induced colitis was relieved in Ticam1Lps2/Ticam1Lps2 (TRIF-KO) mice compared with wild-type (WT) mice. Mutant (n = 14) and WT (n = 21) mice were fed with DSS (3%) for total 9 days, and mice were treated with flagellin enema (0.8 - 1.0 ug/mouse/day) during the last 5 days. B, representative H&E-stained mid- and proximal colon tissues were prepared from flagellin-exacerbated DSS-induced colitis of mutant and WT mice. Scale bars, 100 um.
Copyright This image is from Choi YJ, J Biol Chem 2010 Nov 26;285(48):37570-8 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:167340
Associated
Alleles
Symbol Name
Ticam1Lps2 TIR domain containing adaptor molecule 1; lipopolysaccharide 2
Associated
Genotypes
Allelic Composition Genetic Background
Ticam1Lps2/Ticam1Lps2 C57BL/6J-Ticam1Lps2

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/24/2023
MGI 6.22
The Jackson Laboratory