All Phenotypes Satb2<+> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Satb2^em3(IMPC)Tcp/Satb2⁺	C57BL/6NCrl-Satb2^em3(IMPC)Tcp/Tcp	MGI:6263423
ht2	Satb2^{tm1b(KOMP)Wtsi}/Satb2⁺	C57BL/6N-Satb2^{tm1b(KOMP)Wtsi}/Ucd	MGI:5757676
ht3	Satb2^tm1(cre)Vit/Satb2⁺	involves: C57BL/6	MGI:3695610
cn4	Mirc21^tm1.1Kry/Mirc21^tm1.1Kry Satb2^tm1Rug/Satb2⁺ Tg(Col1a1-cre)1Kry/0	involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N	MGI:5427924
cx5	Atf4^tm1Tow/Atf4⁺ Satb2^tm1Rug/Satb2⁺	either: (involves: 129P2/OlaHsd * NIH Black Swiss) or (involves: 129S1/Sv * 129X1/SvJ * NIH Black Swiss)	MGI:3696661
cx6	Runx2^tm1Mjo/Runx2⁺ Satb2^tm1Rug/Satb2⁺	Not Specified	MGI:3696662

Allelic Composition	Satb2^em3(IMPC)Tcp/Satb2⁺
Genetic Background	C57BL/6NCrl-Satb2^em3(IMPC)Tcp/Tcp

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Satb2^em3(IMPC)Tcp mutation (2 available); any Satb2 mutation (46 available)

Data Sources

IMPC Data for Satb2

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased mean corpuscular volume ( J:211773 )

IMPC - TCP

homeostasis/metabolism

increased circulating alkaline phosphatase level ( J:211773 )

IMPC - TCP

vision/eye

abnormal retina morphology ( J:211773 )

IMPC - TCP

Allelic Composition	Satb2^{tm1b(KOMP)Wtsi}/Satb2⁺
Genetic Background	C57BL/6N-Satb2^{tm1b(KOMP)Wtsi}/Ucd
Cell Lines	EPD0098_3_H05

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Satb2^{tm1b(KOMP)Wtsi} mutation (1 available); any Satb2 mutation (46 available)

Data Sources

IMPC Data for Satb2

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

enlarged lymph nodes ( J:211773 )

IMPC - TCP

reproductive system

abnormal uterus morphology ( J:211773 )

IMPC - TCP

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:116770 )

• fewer found at weaning than expected (about 35% compared to the expected 50%)

craniofacial

abnormal jaw morphology ( J:116770 )

• at E11.5 a variable increase in apoptosis is seen in the mandibular BA1, maxillary BA1, and frontonasal mesenchyme regions that normally express Satb2

abnormal incisor morphology ( J:116770 )

• variable incisor hypodontia and or adontia

premaxilla hypoplasia ( J:116770 )

abnormal nasal capsule morphology ( J:116770 )

• hypoplasia

decreased mouth size ( J:116770 )

• small mouth

cleft palate ( J:116770 )

• seen in about 1/4 of mice

asymmetric snout ( J:116770 )

• snout is occasionally asymmetric

short snout ( J:116770 )

• snout is strongly truncated

respiratory system

abnormal nasal capsule morphology ( J:116770 )

• hypoplasia

skeleton

abnormal jaw morphology ( J:116770 )

• at E11.5 a variable increase in apoptosis is seen in the mandibular BA1, maxillary BA1, and frontonasal mesenchyme regions that normally express Satb2

abnormal incisor morphology ( J:116770 )

• variable incisor hypodontia and or adontia

premaxilla hypoplasia ( J:116770 )

abnormal nasal capsule morphology ( J:116770 )

• hypoplasia

digestive/alimentary system

cleft palate ( J:116770 )

• seen in about 1/4 of mice

growth/size/body

abnormal jaw morphology ( J:116770 )

• at E11.5 a variable increase in apoptosis is seen in the mandibular BA1, maxillary BA1, and frontonasal mesenchyme regions that normally express Satb2

abnormal incisor morphology ( J:116770 )

• variable incisor hypodontia and or adontia

premaxilla hypoplasia ( J:116770 )

abnormal nasal capsule morphology ( J:116770 )

• hypoplasia

decreased mouth size ( J:116770 )

• small mouth

cleft palate ( J:116770 )

• seen in about 1/4 of mice

asymmetric snout ( J:116770 )

• snout is occasionally asymmetric

short snout ( J:116770 )

• snout is strongly truncated

microcephaly ( J:116770 )

• slight

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
isolated cleft palate		DOID:0110213	OMIM:119540	J:116770

Allelic Composition	Mirc21^tm1.1Kry/Mirc21^tm1.1Kry Satb2^tm1Rug/Satb2⁺ Tg(Col1a1-cre)1Kry/0
Genetic Background	involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc21^tm1.1Kry mutation (0 available); any Mirc21 mutation (5 available)
Satb2^tm1Rug mutation (0 available); any Satb2 mutation (46 available)
Tg(Col1a1-cre)1Kry mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

skeleton phenotype ( J:185130 )

N	• mice exhibit normal bone mass, bone formation rate and osteoblast numbers

Allelic Composition	Atf4^tm1Tow/Atf4⁺ Satb2^tm1Rug/Satb2⁺
Genetic Background	either: (involves: 129P2/OlaHsd * NIH Black Swiss) or (involves: 129S1/Sv * 129X1/SvJ * NIH Black Swiss)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atf4^tm1Tow mutation (1 available); any Atf4 mutation (23 available)
Satb2^tm1Rug mutation (0 available); any Satb2 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal bone structure ( J:115876 )

decreased bone volume ( J:115876 )

• bone volume/total volume is reduced from 15.5% in wild-type to 8.53% in mutants

decreased bone trabecula number ( J:115876 )

• trabecular numbers/mm are reduced from 4.54 in wild-type to 2.48 in mutants

decreased bone ossification ( J:115876 )

• display a marked reduction of bone formation at E15.5

Allelic Composition	Runx2^tm1Mjo/Runx2⁺ Satb2^tm1Rug/Satb2⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx2^tm1Mjo mutation (0 available); any Runx2 mutation (44 available)
Satb2^tm1Rug mutation (0 available); any Satb2 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal bone structure ( J:115876 )

decreased bone volume ( J:115876 )

• bone volume/total volume is reduced from 15.5% in wild-type to 3.53% in mutants

decreased bone trabecula number ( J:115876 )

• trabecular numbers/mm are reduced from 4.54 in wild-type to 0.79 in mutants

abnormal bone ossification ( J:115876 )

• display a marked reduction of bone formation at E15.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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