Analysis Tools
mortality/aging
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• death during early gestation, prior to E7
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Allele Symbol Allele Name Allele ID |
Camltm1Rjb targeted mutation 1, Richard J Bram MGI:2678819 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• death during early gestation, prior to E7
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• double-positive thymocytes from mutant mice undergo enhanced apoptosis by TCR-stimulation
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• the average numbers of total thymocytes were reduced by half
• the number of cells at the double-negative stage was not different
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• 4- to 6-fold fewer CD4 and CD8 single-positive cells compared to control
• in 3-4 weeks old mutant mice, there were 7- to 9-fold fewer peripheral CD4+ and CD8+ T cells
• in 8-9 weeks old mutant mice, T cell numbers were more similar
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• double-positive thymocytes from mutant mice undergo enhanced apoptosis by TCR-stimulation
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• the average numbers of total thymocytes were reduced by half
• the number of cells at the double-negative stage was not different
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• 4- to 6-fold fewer CD4 and CD8 single-positive cells compared to control
• in 3-4 weeks old mutant mice, there were 7- to 9-fold fewer peripheral CD4+ and CD8+ T cells
• in 8-9 weeks old mutant mice, T cell numbers were more similar
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• double-positive thymocytes from mutant mice undergo enhanced apoptosis by TCR-stimulation
|
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• the average numbers of total thymocytes were reduced by half
• the number of cells at the double-negative stage was not different
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• reduced numbers of total thymocytes
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• in an in vitro assay, mutant thymocytes underwent OCA peptide 257-264 dependent cell death more readily than control, indicating enhanced negative selection
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• lower proportions of double-positive and single-positive cells, and reduced CD8 SP cell in the peripheral T cell population, both indicating impaired positive selection
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• reduced numbers of total thymocytes
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• in an in vitro assay, mutant thymocytes underwent OCA peptide 257-264 dependent cell death more readily than control, indicating enhanced negative selection
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• lower proportions of double-positive and single-positive cells, and reduced CD8 SP cell in the peripheral T cell population, both indicating impaired positive selection
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• reduced numbers of total thymocytes
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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