Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkbtm1Cgn mutation
(0 available);
any
Ikbkb mutation
(54 available)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation
(11 available);
any
Cd19 mutation
(56 available)
Ikbkbtm1.1Cgn mutation
(0 available);
any
Ikbkb mutation
(54 available)
Ikbkbtm1Cgn mutation
(0 available);
any
Ikbkb mutation
(54 available)
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immune system
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• B cell turnover over a one week period is almost twice that of controls
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• immature B cell numbers in the spleen are reduced by about a half
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• there is a 2- to 4- fold reduction in the number of mature recirculating B cells found in the bone marrow
• the IgMlowIgD+ mature B cell population is strongly diminished in the spleen by 3- to 4- fold
• B cell numbers in the lymph nodes are also strongly reduced
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• B-1 B cell numbers are strongly decreased in the peritoneum cavity
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• follicular B cells are the most diminished B cell population in the spleen
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• marginal zone B cell numbers are reduced about 4-fold
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hematopoietic system
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• B cell turnover over a one week period is almost twice that of controls
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• immature B cell numbers in the spleen are reduced by about a half
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• there is a 2- to 4- fold reduction in the number of mature recirculating B cells found in the bone marrow
• the IgMlowIgD+ mature B cell population is strongly diminished in the spleen by 3- to 4- fold
• B cell numbers in the lymph nodes are also strongly reduced
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• B-1 B cell numbers are strongly decreased in the peritoneum cavity
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• follicular B cells are the most diminished B cell population in the spleen
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• marginal zone B cell numbers are reduced about 4-fold
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cellular
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• B cell turnover over a one week period is almost twice that of controls
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkbtm1Cgn mutation
(0 available);
any
Ikbkb mutation
(54 available)
Tg(KRT14-cre)1Cgn mutation
(2 available)
Tnfrsf1atm1Mak mutation
(2 available);
any
Tnfrsf1a mutation
(47 available)
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integument
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N |
• mice reach adulthood without showing inflammatory skin lesions
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkbtm1Cgn mutation
(0 available);
any
Ikbkb mutation
(54 available)
Tg(KRT14-cre)1Cgn mutation
(2 available)
Tnfrsf1atm1Mak mutation
(2 available);
any
Tnfrsf1a mutation
(47 available)
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integument
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N |
• mice reach adulthood without showing inflammatory skin lesions
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkbtm1Cgn mutation
(0 available);
any
Ikbkb mutation
(54 available)
Tg(KRT14-cre)1Cgn mutation
(2 available)
Tnfrsf1atm2Gkl mutation
(1 available);
any
Tnfrsf1a mutation
(47 available)
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integument
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• at P7
• skin lesions progressively develop to severe skin inflammation by 4 weeks
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• milder at P7 than in Ikbkbtm1Cgn/Ikbkbtm1Cgn Tg(KRT14-cre)1Cgn
• skin lesions progressively develop to severe skin inflammation by 4 weeks
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immune system
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• at P7
• skin lesions progressively develop to severe skin inflammation by 4 weeks
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkbtm1Cgn mutation
(0 available);
any
Ikbkb mutation
(54 available)
Il22ra1tm1Rsab mutation
(0 available);
any
Il22ra1 mutation
(30 available)
Tg(KRT14-cre)1Cgn mutation
(2 available)
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mortality/aging
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N |
• mice survive to adulthood
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integument
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• delayed onset and decelerated development compared with Ikbkbtm1Cgn/Ikbkbtm1Cgn Tg(KRT14-cre)1Cgn
• mild inflammation at 7 weeks
• cutaneous inflammation of variable degree on the abdomen, flanks and throat at 14 weeks
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• at P8, milder than in Ikbkbtm1Cgn/Ikbkbtm1Cgn Tg(KRT14-cre)1Cgn
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• delayed onset and decelerated development compared with Ikbkbtm1Cgn/Ikbkbtm1Cgn Tg(KRT14-cre)1Cgn
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immune system
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• delayed onset and decelerated development compared with Ikbkbtm1Cgn/Ikbkbtm1Cgn Tg(KRT14-cre)1Cgn
• mild inflammation at 7 weeks
• cutaneous inflammation of variable degree on the abdomen, flanks and throat at 14 weeks
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkbtm1.1Cgn mutation
(0 available);
any
Ikbkb mutation
(54 available)
Ikbkbtm1Cgn mutation
(0 available);
any
Ikbkb mutation
(54 available)
Tg(Cd4-cre)1Cwi mutation
(10 available)
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immune system
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• spleen and lymph nodes are nearly devoid of T cells
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• only a mild reduction in the CD4 single-positive cells in the thymus
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• 50% reduction in CD8 single-positive cells in the thymus
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• loss of single positive thymocytes during final maturation stages in the thymus
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hematopoietic system
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• spleen and lymph nodes are nearly devoid of T cells
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• only a mild reduction in the CD4 single-positive cells in the thymus
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• 50% reduction in CD8 single-positive cells in the thymus
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• loss of single positive thymocytes during final maturation stages in the thymus
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkbtm1Cgn mutation
(0 available);
any
Ikbkb mutation
(54 available)
Il20ratm1Rsab mutation
(0 available);
any
Il20ra mutation
(30 available)
Tg(KRT14-cre)1Cgn mutation
(2 available)
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mortality/aging
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• severe inflammation requiring euthanasia by P25 in some mice
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integument
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• delayed onset and decelerated development compared with Ikbkbtm1Cgn/Ikbkbtm1Cgn Tg(KRT14-cre)1Cgn
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• delayed onset and decelerated development compared with Ikbkbtm1Cgn/Ikbkbtm1Cgn Tg(KRT14-cre)1Cgn
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immune system
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• delayed onset and decelerated development compared with Ikbkbtm1Cgn/Ikbkbtm1Cgn Tg(KRT14-cre)1Cgn
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkbtm1Cgn mutation
(0 available);
any
Ikbkb mutation
(54 available)
Tg(KRT14-cre)1Cgn mutation
(2 available)
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integument
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• psoriasis-like skin inflammation
• inflammatory infiltrate consists mainly of macrophages and dendritic cells rather than CD3+ T lymphocytes
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• psoriasis-like skin inflammation
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immune system
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• psoriasis-like skin inflammation
• inflammatory infiltrate consists mainly of macrophages and dendritic cells rather than CD3+ T lymphocytes
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkbtm1Cgn mutation
(0 available);
any
Ikbkb mutation
(54 available)
Il22tm1Jcrd mutation
(0 available);
any
Il22 mutation
(27 available)
Tg(KRT14-cre)1Cgn mutation
(2 available)
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mortality/aging
integument
immune system
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkbtm1Cgn mutation
(0 available);
any
Ikbkb mutation
(54 available)
Tg(Lck-cre)I57Jxm mutation
(1 available)
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immune system
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• CD4+ T cell numbers are reduced in the spleen and lymph nodes
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• CD8+ T cell numbers are reduced in the spleen and lymph nodes
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hematopoietic system
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• CD4+ T cell numbers are reduced in the spleen and lymph nodes
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• CD8+ T cell numbers are reduced in the spleen and lymph nodes
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Analysis Tools