Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crhr1tm2Wrst mutation
(0 available);
any
Crhr1 mutation
(26 available)
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normal phenotype
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• homozygotes do not display any behavioral or neuroendocrine phenotype
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crhr1tm2Wrst mutation
(0 available);
any
Crhr1 mutation
(26 available)
Neurod6tm1(cre)Kan mutation
(0 available);
any
Neurod6 mutation
(17 available)
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behavior/neurological
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N |
• mice exhibit normal behavior in a forced swim test and auditory fear conditioning
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• in a dark-light box, elevated plus maze, and novel object exploration tests
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nervous system
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• mice exhibit increased corticosterone-releasing hormone (CRH)-evoked excitatory field potentials on glutamatergic neurons compared with control mice
• CRH fails to enhance propagation of neuronal activity from hippocampal input region and CA1 input compared with control mice
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crhr1tm2Wrst mutation
(0 available);
any
Crhr1 mutation
(26 available)
Tg(Camk2a-cre)159Kln mutation
(0 available)
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behavior/neurological
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• in the light-dark box paradigm, mutant mice spend significantly more time in the lit compartment, display a decresead latency to enter the lit compartment, and show a signicantly higher number of entries into the lit compartment than control mice; however, no significant differences in the number of entries into the dark compartment are observed
• in the elevated plus maze test, mutant mice display significantly fewer head-dips in the protected arms as a percentage of total head dips, and an increase in the percentage of entries into the open arms; however, no significant differences in the number of entries into the closed arms are observed
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• mutant mice display increased locomotor activity in the open-field paradigm
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crhr1tm2Wrst mutation
(0 available);
any
Crhr1 mutation
(26 available)
Tg(Nes-cre)1Kln mutation
(4 available)
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behavior/neurological
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N |
• mice exhibit normal anxiety-related behavior
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crhr1tm2Wrst mutation
(0 available);
any
Crhr1 mutation
(26 available)
Tg(Fev-cre)1Esd mutation
(1 available)
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behavior/neurological
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N |
• mice exhibit normal behavior in a forced swim test and auditory fear conditioning
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• in a dark-light box, elevated plus maze, the novel object exploration, and modified hole board tests
• hypoactivity in the first 5 minutes of the open field test
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• in the first 5 minutes of the open field test
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nervous system
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• mice exhibit decreased stress-induced dopamine release in the pre-frontal cortex compared with control mice
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crhr1tm2Wrst mutation
(0 available);
any
Crhr1 mutation
(26 available)
Tg(Slc6a3-cre/ERT2)1Span mutation
(0 available)
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behavior/neurological
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N |
• tamoxifen-treated mice exhibit normal anxiety-related behavior, behavior in a forced swim test, and auditory fear conditioning
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crhr1tm2Wrst mutation
(0 available);
any
Crhr1 mutation
(26 available)
Tg(dlx5a-cre)1Mekk mutation
(2 available)
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behavior/neurological
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N |
• mice exhibit normal anxiety-related behavior, forced swim test, and auditory fear conditioning
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homeostasis/metabolism
Analysis Tools
