All Phenotypes Pdpk1<tm1Mlw> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pdpk1^tm1Mlw/Pdpk1^tm1Mlw	involves: BALB/c	MGI:2677528
ht2	Pdpk1^tm1Mlw/Pdpk1^tm1.2Mlw	involves: BALB/c	MGI:2677556
cn3	Pdpk1^tm1Mlw/Pdpk1^tm1.1Daca Tg(Cd4-cre)1Cwi/0	involves: 129P2/OlaHsd * BALB/c * C57BL/6 * DBA/2	MGI:4838171
cn4	Kras^tm4Tyj/Kras⁺ Pdpk1^tm1Mlw/Pdpk1^tm1Mlw Tg(Cela1-cre/ERT)1Dam/0	involves: 129S4/SvJae	MGI:5510699
cn5	Kras^tm4Tyj/Kras⁺ Pdpk1^tm1Mlw/Pdpk1^tm1Mlw Ptf1a^tm1(cre)Hnak/Ptf1a⁺	involves: 129S4/SvJae	MGI:5510701
cn6	Gt(ROSA)26Sor^{tm2(Pik3ca*)Dsa}/Gt(ROSA)26Sor⁺ Kras^tm4Tyj/Kras⁺ Pdpk1^tm1Mlw/Pdpk1^tm1Mlw Ptf1a^tm1(cre)Hnak/Ptf1a⁺	involves: 129S4/SvJae * 129S6/SvEvTac	MGI:5510696
cn7	Gt(ROSA)26Sor^{tm2(Pik3ca*)Dsa}/Gt(ROSA)26Sor⁺ Pdpk1^tm1Mlw/Pdpk1^tm1Mlw Ptf1a^tm1(cre)Hnak/Ptf1a⁺	involves: 129S6/SvEvTac	MGI:5510695
cn8	Pdpk1^tm1Mlw/Pdpk1^tm1Mlw Tg(Cd4-cre)1Cwi/0	involves: C57BL/6 * DBA/2	MGI:4838172

Allelic Composition	Pdpk1^tm1Mlw/Pdpk1^tm1Mlw
Genetic Background	involves: BALB/c

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Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdpk1^tm1Mlw mutation (0 available); any Pdpk1 mutation (138 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:85894 )

• homozygotes born at 5% lower ratio than expected

growth/size/body

decreased birth body size ( J:85894 )

• animals of both sexes about 30% smaller at birth

decreased body size ( J:85894 )

• animals of both sexes remain smaller throughout their adult life

decreased body weight ( J:85894 )

• in females, difference in weight remains ~30% at 6 months of age

• in males, difference in weight is increased to ~45% by 6 months of age

Allelic Composition	Pdpk1^tm1Mlw/Pdpk1^tm1.2Mlw
Genetic Background	involves: BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdpk1^tm1.2Mlw mutation (0 available); any Pdpk1 mutation (138 available)
Pdpk1^tm1Mlw mutation (0 available); any Pdpk1 mutation (138 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:85894 )

• homozygotes born at 25% lower ratio than expected

growth/size/body

decreased body size ( J:85894 )

• males about 45-50% smaller at birth

• females about 35% smaller at birth

• kidney, pancreas, spleen, adrenal gland all 50% smaller in size

• due to smaller cells

Allelic Composition	Pdpk1^tm1Mlw/Pdpk1^tm1.1Daca Tg(Cd4-cre)1Cwi/0
Genetic Background	involves: 129P2/OlaHsd * BALB/c * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdpk1^tm1.1Daca mutation (0 available); any Pdpk1 mutation (138 available)
Pdpk1^tm1Mlw mutation (0 available); any Pdpk1 mutation (138 available)
Tg(Cd4-cre)1Cwi mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased T cell number ( J:165626 )

• T cells are decreased in the liver compared to in wild-type mice

decreased NK T cell number ( J:165626 )

• NK1.1-/CD44- stage 1 through 3 cells are decreased compared to in wild-type mice

• invariant NK T cell numbers in peripheral tissues (spleen, blood, and liver) is severely decreased compared to in wild-type mice

abnormal CD8-positive, alpha beta T cell morphology ( J:165626 )

• CD8+ thymocytes exhibit reduced surface expression of CD8 compared to in wild-type mice

hematopoietic system

decreased T cell number ( J:165626 )

• T cells are decreased in the liver compared to in wild-type mice

decreased NK T cell number ( J:165626 )

• NK1.1-/CD44- stage 1 through 3 cells are decreased compared to in wild-type mice

• invariant NK T cell numbers in peripheral tissues (spleen, blood, and liver) is severely decreased compared to in wild-type mice

abnormal CD8-positive, alpha beta T cell morphology ( J:165626 )

• CD8+ thymocytes exhibit reduced surface expression of CD8 compared to in wild-type mice

Allelic Composition	Kras^tm4Tyj/Kras⁺ Pdpk1^tm1Mlw/Pdpk1^tm1Mlw Tg(Cela1-cre/ERT)1Dam/0
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm4Tyj mutation (9 available); any Kras mutation (76 available)
Pdpk1^tm1Mlw mutation (0 available); any Pdpk1 mutation (138 available)
Tg(Cela1-cre/ERT)1Dam mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:197054 )

N	• mice do not develop pancreatic tumors unlike Kras^tm4Tyj/Kras⁺ Tg(Ela1-cre/ERT)1Dam mice

increased lung non-small cell carcinoma incidence ( J:197054 )

respiratory system

increased lung non-small cell carcinoma incidence ( J:197054 )

Allelic Composition	Kras^tm4Tyj/Kras⁺ Pdpk1^tm1Mlw/Pdpk1^tm1Mlw Ptf1a^tm1(cre)Hnak/Ptf1a⁺
Genetic Background	involves: 129S4/SvJae

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♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal pancreas morphology ( J:197054 )

• pancreas of older mice exhibit some areas of fatty degeneration

• however, acinar to ductal metaplasia observed in acini from Kras^tm4Tyj Ptf1a^tm1(cre)Hnak double heterozygotes is rescued in an in vitro assay

neoplasm

neoplasm ( J:197054 )

N	• pancreatic intraepithelial neoplasia and pancreatic ductal adenocarcinoma observed in Kras^tm4Tyj Ptf1a^tm1(cre)Hnak double heterozygotes is rescued

Allelic Composition	Gt(ROSA)26Sor^{tm2(Pik3ca*)Dsa}/Gt(ROSA)26Sor⁺ Kras^tm4Tyj/Kras⁺ Pdpk1^tm1Mlw/Pdpk1^tm1Mlw Ptf1a^tm1(cre)Hnak/Ptf1a⁺
Genetic Background	involves: 129S4/SvJae * 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm2(Pik3ca*)Dsa} mutation (0 available); any Gt(ROSA)26Sor mutation (944 available)
Kras^tm4Tyj mutation (9 available); any Kras mutation (76 available)
Pdpk1^tm1Mlw mutation (0 available); any Pdpk1 mutation (138 available)
Ptf1a^tm1(cre)Hnak mutation (1 available); any Ptf1a mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:197054 )

N	• mice do not develop acinar to ductal metaplasia

neoplasm

neoplasm ( J:197054 )

N	• mice do not develop pancreatic intraepithelial neoplasia or pancreatic ductal adenocarcinoma

Allelic Composition	Gt(ROSA)26Sor^{tm2(Pik3ca*)Dsa}/Gt(ROSA)26Sor⁺ Pdpk1^tm1Mlw/Pdpk1^tm1Mlw Ptf1a^tm1(cre)Hnak/Ptf1a⁺
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm2(Pik3ca*)Dsa} mutation (0 available); any Gt(ROSA)26Sor mutation (944 available)
Pdpk1^tm1Mlw mutation (0 available); any Pdpk1 mutation (138 available)
Ptf1a^tm1(cre)Hnak mutation (1 available); any Ptf1a mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:197054 )

N	• mice do not develop acinar to ductal metaplasia

neoplasm

neoplasm ( J:197054 )

N	• mice do not develop pancreatic intraepithelial neoplasia or pancreatic ductal adenocarcinoma

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased T cell proliferation ( J:165626 )

• T cells are defective in homeostatic proliferation in a lymphopenic host compared with similarly treated wild-type cells

abnormal T cell differentiation ( J:165626 )

• T cell egression from the thymus is impaired compared to in wild-type mice

decreased T cell number ( J:165626 )

• the number of conventional alpha/beta T cells are reduced in the liver, spleen, lymph nodes, and blood compared with wild-type mice

decreased NK T cell number ( J:165626 )

• NK1.1-/CD44- stage 1 cells are decreased 4-fold compared to in wild-type mice

• NK1.1-/CD44- stage 2 and 3 cells are decreased greater than 4-fold compared to in wild-type mice

absent NK T cells ( J:165626 )

• invariant NK T cells are absent from the liver unlike in wild-type mice

• however, mice exhibit normal frequencies of conventional NK cells in the liver

abnormal CD8-positive, alpha beta T cell morphology ( J:165626 )

• CD8+ cells exhibit reduced surface expression of CD8 compared to in wild-type mice

• TCRbeta^high CD8+ single positive thymocytes exhibit a 2-fold reduction in CD8 expression compared with wild-type cells

abnormal NK T cell morphology ( J:165626 )

• invariant NK T cell development is blocked as cells transit stage 1

immune system

immune system phenotype ( J:165626 )

N	• thymocyte numbers and the subpopulations are normal

decreased T cell proliferation ( J:165626 )

• T cells are defective in homeostatic proliferation in a lymphopenic host compared with similarly treated wild-type cells

abnormal T cell differentiation ( J:165626 )

• T cell egression from the thymus is impaired compared to in wild-type mice

decreased T cell number ( J:165626 )

• the number of conventional alpha/beta T cells are reduced in the liver, spleen, lymph nodes, and blood compared with wild-type mice

decreased NK T cell number ( J:165626 )

• NK1.1-/CD44- stage 1 cells are decreased 4-fold compared to in wild-type mice

• NK1.1-/CD44- stage 2 and 3 cells are decreased greater than 4-fold compared to in wild-type mice

absent NK T cells ( J:165626 )

• invariant NK T cells are absent from the liver unlike in wild-type mice

• however, mice exhibit normal frequencies of conventional NK cells in the liver

abnormal CD8-positive, alpha beta T cell morphology ( J:165626 )

• CD8+ cells exhibit reduced surface expression of CD8 compared to in wild-type mice

• TCRbeta^high CD8+ single positive thymocytes exhibit a 2-fold reduction in CD8 expression compared with wild-type cells

abnormal NK T cell morphology ( J:165626 )

• invariant NK T cell development is blocked as cells transit stage 1

cellular

decreased T cell proliferation ( J:165626 )

• T cells are defective in homeostatic proliferation in a lymphopenic host compared with similarly treated wild-type cells

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