Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zap70tm1Dlo mutation
(0 available);
any
Zap70 mutation
(55 available)
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hematopoietic system
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• 95% of thymocytes are double positive T cells and CD69-
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immune system
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• 95% of thymocytes are double positive T cells and CD69-
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zap70m1Saka mutation
(1 available);
any
Zap70 mutation
(55 available)
Zap70tm1Dlo mutation
(0 available);
any
Zap70 mutation
(55 available)
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immune system
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• mice develop arthritis spontaneously by 3 months of age
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skeleton
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• mice develop arthritis spontaneously by 3 months of age
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zap70st mutation
(0 available);
any
Zap70 mutation
(55 available)
Zap70tm1Dlo mutation
(0 available);
any
Zap70 mutation
(55 available)
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hematopoietic system
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• thymocytes fail to mature beyond the double positive stage
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immune system
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• thymocytes fail to mature beyond the double positive stage
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation
(3 available);
any
Cd79a mutation
(22 available)
Syktm1Kuro mutation
(0 available);
any
Syk mutation
(42 available)
Zap70tm1Dlo mutation
(0 available);
any
Zap70 mutation
(55 available)
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immune system
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• there is a complete block pro-B cell differentation at the BP-1+HASlow stage
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hematopoietic system
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• there is a complete block pro-B cell differentation at the BP-1+HASlow stage
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Lck-ZAP70)824Saka mutation
(0 available)
Zap70m1Saka mutation
(1 available);
any
Zap70 mutation
(55 available)
Zap70tm1Dlo mutation
(0 available);
any
Zap70 mutation
(55 available)
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normal phenotype
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• expression of transgene completely inhibits development of arthritis and corrects immunological abnormalities observed in Zap70-deficient mice
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