All Phenotypes Map3k1<tm1Yxia> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Map3k1^tm1Yxia/Map3k1^tm1Yxia	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:2676659
hm2	Map3k1^tm1Yxia/Map3k1^tm1Yxia	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:5699113
hm3	Map3k1^tm1Yxia/Map3k1^tm1Yxia	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:6384030
ht4	Map3k1^tm1Yxia/Map3k1⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:5699114
ht5	Map3k1^goya/Map3k1^tm1Yxia	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:5699115
cx6	Map3k1^tm1Yxia/Map3k1⁺ Mapk8^tm1Wag/Mapk8^tm1Wag	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * CD-1	MGI:6384031
cx7	Map3k1^tm1Yxia/Map3k1⁺ Mapk8^tm1Wag/Mapk8⁺ Mapk9^tm1Mka/Mapk9⁺	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * CD-1	MGI:6384032

Allelic Composition	Map3k1^tm1Yxia/Map3k1^tm1Yxia
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k1^tm1Yxia mutation (0 available); any Map3k1 mutation (63 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal eyelid morphology ( J:85346 )

• at E15.5, the eyelid tip epithelium is thinner than normal; however, number of cell layers is normal

• at E15.5, the mutant eyelid epithelium displays tight cell-cell contacts with signifcantly fewer and smaller intercellular spaces, unlike in wild-type controls

• no abnormal eyelid morphology is noted at E14.5

• by E16, the mutant eyelid fails to move forward, leaving the ocular surface exposed

abnormal eyelid development ( J:85346 )

abnormal eyelid fusion ( J:85346 )

• impaired eyelid closure is noted at E16

abnormal eyelid margin morphology ( J:85346 )

• at E15.5, no clumps of round cells are detected along the mutant eyelid margin, unlike in wild-type controls

eyelids open at birth ( J:85346 )

• all homozygotes exhibit eyelids open at birth

integument

abnormal keratinocyte morphology ( J:85346 )

• keratinocytes ineffective in wound closure

Allelic Composition	Map3k1^tm1Yxia/Map3k1^tm1Yxia
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k1^tm1Yxia mutation (0 available); any Map3k1 mutation (63 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

decreased cochlear inner hair cell number ( J:226897 )

• slight at 9 weeks

increased cochlear outer hair cell number ( J:226897 )

• at 2 weeks

• however, mice exhibit normal outer hair cell proliferation

cochlear outer hair cell degeneration ( J:226897 )

• at 4 weeks with increasing severity from apex to base

• further degeneration at 9 weeks

organ of Corti degeneration ( J:226897 )

• very severe in small patches

• inner hair cells, outer hair cells and pillar cells are replaced with rosette-like formation composed of Claudius and Hensen cells at 9 weeks

increased or absent threshold for auditory brainstem response ( J:226897 )

• at 2, 4 and 9 weeks of age

deafness ( J:226897 )

nervous system

decreased cochlear inner hair cell number ( J:226897 )

• slight at 9 weeks

increased cochlear outer hair cell number ( J:226897 )

• at 2 weeks

• however, mice exhibit normal outer hair cell proliferation

cochlear outer hair cell degeneration ( J:226897 )

• at 4 weeks with increasing severity from apex to base

• further degeneration at 9 weeks

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

increased retina apoptosis ( J:176244 )

• the number of apoptotic cells is increased in the retina at P14-P21

abnormal iris morphology ( J:176244 )

• iris overgrowth

• however, Meibomian glands are normal

abnormal cornea morphology ( J:176244 )

abnormal cornea stroma morphology ( J:176244 )

• stromal neovascularization and thickening of the cornea

• corneas show macrophage invasion in the stroma

• surgical suture of the eyelid partially restores normal corneal appearance and reduces macrophage invasion

increased cornea stroma thickness ( J:176244 )

• stromal thickening

• surgical suture of the eyelid partially restores normal corneal appearance and reduces corneal thickening

cornea opacity ( J:176244 )

• cloudiness of the cornea

early eyelid opening ( J:176244 )

• eyes open at birth

abnormal retina morphology ( J:176244 )

• retinas start to show misallocated cell bodies at the posterior side at P7 and develop sporadic rosette structures posterior to the photoreceptor layers at P15

• retina shows invasion of macrophages at 1 year of age

retina neovascularization ( J:176244 )

• localized neo-vascularization in RPE and outer nuclear layer

abnormal Muller cell morphology ( J:176244 )

• an increase in late-born Muller glial cells is seen in retinas

• Muller glial processes protrude beyond the boundary of the outer limiting membrane and displace the rod photoreceptors in hyperplastic lesions

retina photoreceptor degeneration ( J:176244 )

abnormal retina pigment epithelium morphology ( J:176244 )

• mice show broken down retinal pigment epithelium (RPE) resulting in focal RPE leak

abnormal retina development ( J:176244 )

• the number of mitotic progenitors is slightly increased at P6 and significantly higher at P7 and P8 at the outer edge of the retina and some mitotic progenitors are located in unusual positions in the inner segment of the retinas

• S-phase+ cells are more abundant at P6-P10 in the retina, especially in peripheral regions

• however, mitosis ceases at P12 in the retina as in controls

abnormal retina outer nuclear layer morphology ( J:176244 )

• regional dislocalization in the outer nuclear layer and rosette-like arrangements in this layer

• mice with opened eyelids sutured closed right after birth and suture removed at P14 when eyelids open normally show rosette structure in the outer nuclear layer at P15

thin retina outer nuclear layer ( J:176244 )

• thinner outer nuclear layer at 1 year of age

retina degeneration ( J:176244 )

• signs of retinal degeneration are seen at 1 year of age

retina gliosis ( J:176244 )

• some Muller glia nuclei undergo mitosis and migrate out of the inner nuclear layer, indicating proliferative gliosis

cardiovascular system

retina neovascularization ( J:176244 )

• localized neo-vascularization in RPE and outer nuclear layer

cellular

abnormal Muller cell morphology ( J:176244 )

• an increase in late-born Muller glial cells is seen in retinas

• Muller glial processes protrude beyond the boundary of the outer limiting membrane and displace the rod photoreceptors in hyperplastic lesions

increased retina apoptosis ( J:176244 )

• the number of apoptotic cells is increased in the retina at P14-P21

nervous system

abnormal Muller cell morphology ( J:176244 )

• an increase in late-born Muller glial cells is seen in retinas

• Muller glial processes protrude beyond the boundary of the outer limiting membrane and displace the rod photoreceptors in hyperplastic lesions

retina photoreceptor degeneration ( J:176244 )

pigmentation

abnormal retina pigment epithelium morphology ( J:176244 )

• mice show broken down retinal pigment epithelium (RPE) resulting in focal RPE leak

Allelic Composition	Map3k1^tm1Yxia/Map3k1⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k1^tm1Yxia mutation (0 available); any Map3k1 mutation (63 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

increased cochlear outer hair cell number ( J:226897 )

• however, mice do not exhibit outer hair cell degeneration

nervous system

increased cochlear outer hair cell number ( J:226897 )

• however, mice do not exhibit outer hair cell degeneration

Allelic Composition	Map3k1^goya/Map3k1^tm1Yxia
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k1^goya mutation (0 available); any Map3k1 mutation (63 available)
Map3k1^tm1Yxia mutation (0 available); any Map3k1 mutation (63 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

increased or absent threshold for auditory brainstem response ( J:226897 )

• at 9 weeks of age with an apical-to-basal gradient

deafness ( J:226897 )

Allelic Composition	Map3k1^tm1Yxia/Map3k1⁺ Mapk8^tm1Wag/Mapk8^tm1Wag
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k1^tm1Yxia mutation (0 available); any Map3k1 mutation (63 available)
Mapk8^tm1Wag mutation (1 available); any Mapk8 mutation (76 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

early eyelid opening ( J:176244 )

• eyes are open at birth

• however, mice exhibit normal retinal morphology

Allelic Composition	Map3k1^tm1Yxia/Map3k1⁺ Mapk8^tm1Wag/Mapk8⁺ Mapk9^tm1Mka/Mapk9⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * CD-1

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

early eyelid opening ( J:176244 )

• eyes are open at birth

• however, mice exhibit normal retinal morphology

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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