Phenotypes associated with this allele

• Allele Symbol: Trpm6⁺
• Allele Name: wild type
• Allele ID: MGI:2675604
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Trpm6^tm1b(KOMP)Wtsi/Trpm6^+	C57BL/6N-Trpm6^tm1b(KOMP)Wtsi/Orl	MGI:6263781
ht2	Trpm6^tm1.1Rws/Trpm6^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N	MGI:4366772

Genotype
MGI:6263781

ht1

• Allelic Composition: Trpm6^{tm1b(KOMP)Wtsi}/Trpm6⁺
• Genetic Background: C57BL/6N-Trpm6^{tm1b(KOMP)Wtsi}/Orl
• Cell Lines: EPD0741_2_G10

Data Sources

IMPC Data for Trpm6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased grip strength ( J:211773 )

♂

IMPC - ICS

growth/size/body

increased body length ( J:211773 )

♂

IMPC - ICS

hematopoietic system

decreased mean corpuscular volume ( J:211773 )

IMPC - ICS

homeostasis/metabolism

decreased circulating phosphate level ( J:211773 )

♂

IMPC - ICS

vision/eye

abnormal eye anterior chamber depth ( J:211773 )

♀

IMPC - ICS

Genotype
MGI:4366772

ht2

• Allelic Composition: Trpm6^tm1.1Rws/Trpm6⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

mortality/aging

premature death ( J:153718 )

• day 60 mortality is 4.7% compared to 0% in wild-type mice whether fed a high magnesium diet or not

homeostasis/metabolism

decreased circulating magnesium level ( J:153718 )

• mice exhibit modestly lower magnesium serum levels than in wild-type mice

• however, renal and fecal excretion of magnesium is normal