Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfrtm2(EGFR)Wag mutation
(0 available);
any
Egfr mutation
(85 available)
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|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfrtm2(EGFR)Wag mutation
(0 available);
any
Egfr mutation
(85 available)
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mortality/aging
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• increased lethality prior to 6 months of age due to cardiac hypertrophy
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• incomplete penetrance, 7% of homozygous mutant mice were born alive
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cardiovascular system
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• contributing to increased lethality
• apparent 3 weeks after birth in some mice
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growth/size/body
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• contributing to increased lethality
• apparent 3 weeks after birth in some mice
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skeleton
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• accelerated osteoblast differentiation
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• accelerated chondrocyte differentiation
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nervous system
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N |
• in contrast to null mice, normal architecture and morphology was observed in various sections of the brain including the frontal cortex, hippocampus, olfactory bulb, thalamus, and cerebellum
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integument
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• by 5 to 7 months of age due to progressive degeneration of hair follicles
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• progressive degeneration and inflammation led to the loss of most follicles over time, leading to baldness by 5 to 7 months of age
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cellular
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• accelerated osteoblast differentiation
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muscle
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|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfrtm1Wag mutation
(0 available);
any
Egfr mutation
(85 available)
Egfrtm2(EGFR)Wag mutation
(0 available);
any
Egfr mutation
(85 available)
|
|
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfrtm1Wag mutation
(0 available);
any
Egfr mutation
(85 available)
Egfrtm2(EGFR)Wag mutation
(0 available);
any
Egfr mutation
(85 available)
|
|
|
Analysis Tools