All Phenotypes In(11Trp53;11Wnt3)8Brd MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	In(11Trp53;11Wnt3)8Brd/In(11Trp53;11Wnt3)8Brd	involves: 129S7/SvEvBrd * C57BL/6Brd	MGI:2673217
cx2	A/a In(11Trp53;11Wnt3)8Brd/+	either: (involves: 129S7/SvEvBrd * C57BL/6Brd) or (involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6Brd) or (involves: 129S5/SvEvBrd * C57BL/6Brd * C57BL/6J)	MGI:5766498
cx3	In(11Trp53;11Wnt3)8Brd/+ Tyr^c-Brd/Tyr^c-Brd	involves: 129S7/SvEvBrd * C57BL/6Brd	MGI:5766501
cx4	a/a In(11Trp53;11Wnt3)8Brd/+	involves: 129S7/SvEvBrd * C57BL/6Brd * C57BL/6J	MGI:5766500
cx5	In(11Trp53;11Wnt3)8Brd/+ Rpl27a^Sfa/Rpl27a⁺	involves: 129S7/SvEvBrd * C57BL/6J	MGI:5140360

Allelic Composition	In(11Trp53;11Wnt3)8Brd/In(11Trp53;11Wnt3)8Brd
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6Brd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
In(11Trp53;11Wnt3)8Brd mutation (1 available); any In(11Trp53;11Wnt3)8Brd mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:56548 )

• homozygous embryos are inviable

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

decreased ear pigmentation ( J:56548 )

• mice heterozygous for this inversion on an agouti background have agouti hair coats, but with light-colored ears due to the Krt14-A transgene in the Wnt3 locus.

growth/size/body

decreased ear pigmentation ( J:56548 )

• mice heterozygous for this inversion on an agouti background have agouti hair coats, but with light-colored ears due to the Krt14-A transgene in the Wnt3 locus.

hearing/vestibular/ear

decreased ear pigmentation ( J:56548 )

• mice heterozygous for this inversion on an agouti background have agouti hair coats, but with light-colored ears due to the Krt14-A transgene in the Wnt3 locus.

integument

decreased ear pigmentation ( J:56548 )

• mice heterozygous for this inversion on an agouti background have agouti hair coats, but with light-colored ears due to the Krt14-A transgene in the Wnt3 locus.

abnormal tail pigmentation ( J:56548 )

• mice heterozygous for this inversion on an agouti background have agouti hair coats, but with light-colored tails due to the Krt14-A transgene in the Wnt3 locus.

limbs/digits/tail

abnormal tail pigmentation ( J:56548 )

• mice heterozygous for this inversion on an agouti background have agouti hair coats, but with light-colored tails due to the Krt14-A transgene in the Wnt3 locus.

pigmentation

decreased ear pigmentation ( J:56548 )

• mice heterozygous for this inversion on an agouti background have agouti hair coats, but with light-colored ears due to the Krt14-A transgene in the Wnt3 locus.

abnormal tail pigmentation ( J:56548 )

• mice heterozygous for this inversion on an agouti background have agouti hair coats, but with light-colored tails due to the Krt14-A transgene in the Wnt3 locus.

Allelic Composition	In(11Trp53;11Wnt3)8Brd/+ Tyr^c-Brd/Tyr^c-Brd
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6Brd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
In(11Trp53;11Wnt3)8Brd mutation (1 available); any In(11Trp53;11Wnt3)8Brd mutation (4 available)
Tyr^c-Brd mutation (6 available); any Tyr mutation (375 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

pigmentation phenotype ( J:56548 )

N	• the inversion has no effect on coat color in an albino background, suggesting the tyrosinase minigene in the Trp53 gene is inactive in the inversion chromosome.

Allelic Composition	a/a In(11Trp53;11Wnt3)8Brd/+
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6Brd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
In(11Trp53;11Wnt3)8Brd mutation (1 available); any In(11Trp53;11Wnt3)8Brd mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal tail pigmentation ( J:56548 )

• mice heterozygous for this inversion on a black, non-agouti background are recognizable by their light-colored tails due to the Krt14-A transgene in the Wnt3 locus.

limbs/digits/tail

abnormal tail pigmentation ( J:56548 )

• mice heterozygous for this inversion on a black, non-agouti background are recognizable by their light-colored tails due to the Krt14-A transgene in the Wnt3 locus.

pigmentation

abnormal tail pigmentation ( J:56548 )

• mice heterozygous for this inversion on a black, non-agouti background are recognizable by their light-colored tails due to the Krt14-A transgene in the Wnt3 locus.

Allelic Composition	In(11Trp53;11Wnt3)8Brd/+ Rpl27a^Sfa/Rpl27a⁺
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
In(11Trp53;11Wnt3)8Brd mutation (1 available); any In(11Trp53;11Wnt3)8Brd mutation (4 available)
Rpl27a^Sfa mutation (0 available); any Rpl27a mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:174216 )

• mice do not display ataxia or foot pad hyperpigmentation

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