All Phenotypes Ctsc<tm1Ley> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ctsc^tm1Ley/Ctsc^tm1Ley	B6.129X1-Ctsc^tm1Ley	MGI:3696455
hm2	Ctsc^tm1Ley/Ctsc^tm1Ley	either: 129X1/SvJ-Ctsc^tm1Ley or (involves: 129X1/SvJ * C57BL/6)	MGI:2671145
cx3	Ctsc^tm1Ley/Ctsc^tm1Ley Ctsh^tm1Thre/Ctsh^tm1Thre	involves: 129P2/OlaHsd * 129X1/SvJ	MGI:4840058
cx4	Ctsc^tm1Ley/Ctsc^tm1Ley Il6^tm1Kopf/Il6^tm1Kopf	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6	MGI:3696456

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal leukocyte migration ( J:131520 )

• following exposure to Sendai virus, leukocyte and more specifically neutrophil recruitment is decreased compared to in wild-type mice

impaired neutrophil recruitment ( J:131520 )

• following exposure to Sendai virus

decreased circulating interleukin-6 level ( J:131520 )

• following exposure to Sendai virus

increased circulating interleukin-6 level ( J:88160 )

• elevated intraperitoneal levels

• serum levels become very high after 24 hours

abnormal chemokine level ( J:131520 )

• following exposure to Sendai virus, CXCL2 levels are reduced compared to in wild-type mice

• however, CXCL1, CXCL5 and CXCL15 levels are normal following exposure to Sendai virus

abnormal response to infection ( J:131520 )

• following exposure to Sendai virus, mice exhibit less severe weight loss than wild-type mice and decreased peribronchial inflammation

• following exposure to Sendai virus, mice exhibit higher viral load and reduced total cell numbers, specifically neutrophils, in bronchoalveolar lavage compared to wild-type mice

• however, mice clear viral load by day 21 post-infection by a normal cytotoxic T cell response and adoptive transfer of wild-type neutrophils into mice can restore the normal response to Sendai virus infection

sepsis ( J:88160 )

• improved survival following cecal ligation and puncture

• initial weight loss greater than in controls but other indications of organ dysfunction are similar to controls

• bacterial load in peritoneum becomes higher than controls by 24 to 48 hours after experimental manipulation and persists for several weeks

homeostasis/metabolism

decreased circulating interleukin-6 level ( J:131520 )

• following exposure to Sendai virus

increased circulating interleukin-6 level ( J:88160 )

• elevated intraperitoneal levels

• serum levels become very high after 24 hours

abnormal chemokine level ( J:131520 )

• following exposure to Sendai virus, CXCL2 levels are reduced compared to in wild-type mice

• however, CXCL1, CXCL5 and CXCL15 levels are normal following exposure to Sendai virus

growth/size/body

weight loss ( J:88160 )

• initial weight loss following cecal ligation and puncture is greater than in controls

cellular

abnormal leukocyte migration ( J:131520 )

• following exposure to Sendai virus, leukocyte and more specifically neutrophil recruitment is decreased compared to in wild-type mice

hematopoietic system

abnormal leukocyte migration ( J:131520 )

• following exposure to Sendai virus, leukocyte and more specifically neutrophil recruitment is decreased compared to in wild-type mice

impaired neutrophil recruitment ( J:131520 )

• following exposure to Sendai virus

Allelic Composition	Ctsc^tm1Ley/Ctsc^tm1Ley
Genetic Background	either: 129X1/SvJ-Ctsc^tm1Ley or (involves: 129X1/SvJ * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctsc^tm1Ley mutation (0 available); any Ctsc mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal enzyme/coenzyme activity ( J:77312 )

• fail to activate granzymes A and B in cytotoxic lymphocytes and in lymphokine activated killer cells

immune system

abnormal T cell physiology ( J:77312 )

• lymphokine activated killer cells have a defect in the ability to cause DNA fragmentation

abnormal cytotoxic T cell physiology ( J:77312 )

• cytotoxic T cells have a defect in the ability to cause DNA fragmentation

hematopoietic system

abnormal T cell physiology ( J:77312 )

• lymphokine activated killer cells have a defect in the ability to cause DNA fragmentation

abnormal cytotoxic T cell physiology ( J:77312 )

• cytotoxic T cells have a defect in the ability to cause DNA fragmentation

Allelic Composition	Ctsc^tm1Ley/Ctsc^tm1Ley Ctsh^tm1Thre/Ctsh^tm1Thre
Genetic Background	involves: 129P2/OlaHsd * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctsc^tm1Ley mutation (0 available); any Ctsc mutation (36 available)
Ctsh^tm1Thre mutation (0 available); any Ctsh mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:165930 )

• mice exhibit normal development, fertility, and lifespan

Allelic Composition	Ctsc^tm1Ley/Ctsc^tm1Ley Il6^tm1Kopf/Il6^tm1Kopf
Genetic Background	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctsc^tm1Ley mutation (0 available); any Ctsc mutation (36 available)
Il6^tm1Kopf mutation (9 available); any Il6 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:88160 )

N	• survival of experimentally induced sepsis is similar to that of controls

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