Analysis Tools
mortality/aging
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• death at E10.5 associated with increased levels of chromosome missegregation, aneuploidy, and apoptosis
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growth/size/body
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• developmental delay is observed at E9.5
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• embryos are 1/10 to 1/3 the size of wild-type embryos at E9.5
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cellular
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• E9.5 embryos contain a high proportion of irregularly shaped interphase nuclei
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• lagging chromosomes are observed during anaphase B in E9.5 embryos
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aneuploidy
(
J:84634
)
|
• high degree of aneuploidy at E9.5, where 34% of cells show a karyotype of 39 chromosomes
|
|
• increase in the level of apopotosis throughout the embryo at E9.5
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embryo
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• developmental delay is observed at E9.5
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• embryos are 1/10 to 1/3 the size of wild-type embryos at E9.5
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• abnormal embryonic morphology including defects in the branchial arch, heart, neural tube, and forebrain
|
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• abnormal at E9.5
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• abnormal at E9.5
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cardiovascular system
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• abnormal at E9.5
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craniofacial
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• abnormal at E9.5
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nervous system
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• abnormal at E9.5
|
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• abnormal at E9.5
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