All Phenotypes Bard1<tm1Thl> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bard1^tm1Thl/Bard1^tm1Thl	involves: 129S1/Sv	MGI:2675365
cn2	Bard1^tm1Thl/Bard1^tm2Thl Tg(Hsp70-1-cre)1Arge/0	involves: 129/Sv * 129S1/Sv * C57BL/6J * CBA	MGI:3805023
cn3	Bard1^tm1Thl/Bard1^tm2Thl Wap^tm1(cre)Arge/0	involves: 129S1/Sv * C57BL/6J	MGI:3805024
cx4	Bard1^tm1Thl/Bard1^tm1Thl Brca1^tm1Arge/Brca1^tm1Arge	involves: 129S/SvEv * 129S1/Sv	MGI:2675414
cx5	Bard1^tm1Thl/Bard1^tm1Thl Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129S1/Sv * 129S2/SvPas	MGI:2675374

Allelic Composition	Bard1^tm1Thl/Bard1^tm1Thl
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bard1^tm1Thl mutation (0 available); any Bard1 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:84329 )

• mutant embryos do not develop past the egg cylinder stage and die between E7.5 and E8.5

• by E8.5 homozygous embryos are undergoing resorption

embryo

abnormal developmental patterning ( J:84329 )

abnormal gastrulation ( J:84329 )

• embryos had reached 2 layer egg cylinder stage at E6.5

• E6.5 embryos were half normal size, most oviouly in embryonic structures

• never developed past egg cylinder stage

• hypoproliferation at E6.5, apoptosis levels normal

abnormal embryonic tissue morphology ( J:84329 )

inner cell mass degeneration ( J:84329 )

• after 2 days of culture ICM from embryos collected at E3.5 started to degenerate

Allelic Composition	Bard1^tm1Thl/Bard1^tm2Thl Tg(Hsp70-1-cre)1Arge/0
Genetic Background	involves: 129/Sv * 129S1/Sv * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bard1^tm1Thl mutation (0 available); any Bard1 mutation (54 available)
Bard1^tm2Thl mutation (0 available); any Bard1 mutation (54 available)
Tg(Hsp70-1-cre)1Arge mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:134977 )

• lethality occurs early in embryonic development

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:134977 )

• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 465 days

• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive

• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate

• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes

• neoplasms often invade in a broad front and push towards the underlying pectoral muscle

• a small minority of tumors have sqaumous characteristics

• pre-cancerous neoplasia are also evident throughout the mammary gland

integument

increased mammary adenocarcinoma incidence ( J:134977 )

• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 465 days

• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive

• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate

• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes

• neoplasms often invade in a broad front and push towards the underlying pectoral muscle

• a small minority of tumors have sqaumous characteristics

• pre-cancerous neoplasia are also evident throughout the mammary gland

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:134977 )

• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 465 days

• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive

• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate

• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes

• neoplasms often invade in a broad front and push towards the underlying pectoral muscle

• a small minority of tumors have sqaumous characteristics

• pre-cancerous neoplasia are also evident throughout the mammary gland

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:134977

Allelic Composition	Bard1^tm1Thl/Bard1^tm1Thl Brca1^tm1Arge/Brca1^tm1Arge
Genetic Background	involves: 129S/SvEv * 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bard1^tm1Thl mutation (0 available); any Bard1 mutation (54 available)
Brca1^tm1Arge mutation (0 available); any Brca1 mutation (113 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality ( J:84329 )

• authors state that this phenotype is identical to homozygous Bard1^tm1Thl

embryo

abnormal developmental patterning ( J:84329 )

• authors state that this phenotype is identical to homozygous Bard1^tm1Thl

abnormal embryonic tissue morphology ( J:84329 )

• authors state that this phenotype is identical to homozygous Bard1^tm1Thl

Allelic Composition	Bard1^tm1Thl/Bard1^tm1Thl Trp53^tm1Tyj/Trp53^tm1Tyj
Genetic Background	involves: 129S1/Sv * 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bard1^tm1Thl mutation (0 available); any Bard1 mutation (54 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:84329 )

• survived through E9.5

cellular

chromosome breakage ( J:84329 )

• 44% of mitotic spreads showed abnormal chromosome number, usually reduced

embryo

decreased embryo size ( J:84329 )

• developmentally retarded by E9.5

open neural tube ( J:84329 )

• seen at E9.5

growth/size/body

decreased embryo size ( J:84329 )

• developmentally retarded by E9.5

nervous system

open neural tube ( J:84329 )

• seen at E9.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23