About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fgfr1tm1.1Jpa
targeted mutation 1.1, Juha Partanen
MGI:2657013
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fgfr1tm1.1Jpa/Fgfr1tm1.1Jpa involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * ICR MGI:2657015
cn2
 		Fgfr1tm1.1Jpa/Fgfr1+
Gt(ROSA)26Sortm5(Etv4/en,-GFP)Amc/Gt(ROSA)26Sor+
Tg(Prrx1-cre)1Cjt/0 		involves: 129 * C57BL/6 * CBA * SJL/J * Swiss Webster MGI:3848913
cn3
 		Fgfr1tm1Jpa/Fgfr1tm1.1Jpa
Fgfr2tm1Dor/Fgfr2+
Twist2tm1(cre)Dor/Twist2+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3813483
cn4
 		Fgfr1tm1Jpa/Fgfr1tm1.1Jpa
Fgfr2tm1Dor/Fgfr2tm1.1Dor
Twist2tm1(cre)Dor/Twist2+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3813486
cn5
 		Fgfr1tm1Jpa/Fgfr1tm1.1Jpa
H2az2Tg(Wnt1-cre)11Rth/H2az2+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * ICR MGI:3703447
cx6
 		Fgfr1tm1.1Jpa/Fgfr1+
Spry2tm1.1Mrt/Spry2tm1.1Mrt 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ MGI:3702559


Genotype
MGI:2657015
hm1
Allelic
Composition		 Fgfr1tm1.1Jpa/Fgfr1tm1.1Jpa
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm1.1Jpa mutation (0 available); any Fgfr1 mutation (219 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

embryo
abnormal gastrulation ( J:83004 )
• gastrulation defects




Genotype
MGI:3848913
cn2
Allelic
Composition		 Fgfr1tm1.1Jpa/Fgfr1+
Gt(ROSA)26Sortm5(Etv4/en,-GFP)Amc/Gt(ROSA)26Sor+
Tg(Prrx1-cre)1Cjt/0
Genetic
Background		 involves: 129 * C57BL/6 * CBA * SJL/J * Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm1.1Jpa mutation (0 available); any Fgfr1 mutation (219 available)
Gt(ROSA)26Sortm5(Etv4/en,-GFP)Amc mutation (0 available); any Gt(ROSA)26Sor mutation (1046 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
abnormal limb development ( J:149478 )
• at P1, mice exhibit a more severe zeugopod phenotypes than in Gt(ROSA)26Sortm5(Etv4/en,-GFP)Amc/Gt(ROSA)26Sor+ Tg(Prrx1-cre)1Cjt mice




Genotype
MGI:3813483
cn3
Allelic
Composition		 Fgfr1tm1Jpa/Fgfr1tm1.1Jpa
Fgfr2tm1Dor/Fgfr2+
Twist2tm1(cre)Dor/Twist2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm1.1Jpa mutation (0 available); any Fgfr1 mutation (219 available)
Fgfr1tm1Jpa mutation (0 available); any Fgfr1 mutation (219 available)
Fgfr2tm1Dor mutation (3 available); any Fgfr2 mutation (91 available)
Twist2tm1(cre)Dor mutation (0 available); any Twist2 mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal small intestine morphology ( J:139005 )
• there is about a 15% reduction in the length of the small intestine at E18.5 compared to controls




Genotype
MGI:3813486
cn4
Allelic
Composition		 Fgfr1tm1Jpa/Fgfr1tm1.1Jpa
Fgfr2tm1Dor/Fgfr2tm1.1Dor
Twist2tm1(cre)Dor/Twist2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm1.1Jpa mutation (0 available); any Fgfr1 mutation (219 available)
Fgfr1tm1Jpa mutation (0 available); any Fgfr1 mutation (219 available)
Fgfr2tm1.1Dor mutation (0 available); any Fgfr2 mutation (91 available)
Fgfr2tm1Dor mutation (3 available); any Fgfr2 mutation (91 available)
Twist2tm1(cre)Dor mutation (0 available); any Twist2 mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal small intestine morphology ( J:139005 )
• there is about a third reduction in the length of the small intestine at E18.5 compared to controls
abnormal small intestine crypts of Lieberkuhn morphology ( J:139005 )
• premature crypt-like structures occur in the small intestine of E18.5 embryos before the appearance of paneth cells
abnormal digestive system physiology ( J:139005 )
• proliferation of fibroblasts found in the proximal and distal small intestine mesenchyme is significantly reduced at E18.5

endocrine/exocrine glands
abnormal small intestine crypts of Lieberkuhn morphology ( J:139005 )
• premature crypt-like structures occur in the small intestine of E18.5 embryos before the appearance of paneth cells




Genotype
MGI:3703447
cn5
Allelic
Composition		 Fgfr1tm1Jpa/Fgfr1tm1.1Jpa
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm1.1Jpa mutation (0 available); any Fgfr1 mutation (219 available)
Fgfr1tm1Jpa mutation (0 available); any Fgfr1 mutation (219 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
craniofacial phenotype ( J:81179 )
N
• at E9.5, no defects are seen in the early development of the second branchial arch unlike mice homozygous for Fgfr1tm2Jrt
abnormal craniofacial bone morphology ( J:81179 )
• no enhancement in later craniofacial phenotypes relative to mice homozygous for Fgfr1tm1Jrt that carry the Tg(Wnt1-cre)11Rth transgene

digestive/alimentary system

skeleton
abnormal craniofacial bone morphology ( J:81179 )
• no enhancement in later craniofacial phenotypes relative to mice homozygous for Fgfr1tm1Jrt that carry the Tg(Wnt1-cre)11Rth transgene

growth/size/body
cleft palate ( J:81179 )




Genotype
MGI:3702559
cx6
Allelic
Composition		 Fgfr1tm1.1Jpa/Fgfr1+
Spry2tm1.1Mrt/Spry2tm1.1Mrt
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm1.1Jpa mutation (0 available); any Fgfr1 mutation (219 available)
Spry2tm1.1Mrt mutation (1 available); any Spry2 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
supernumerary teeth ( J:119280 )
• frequency of diastema tooth formation is reduced to 60% compared to almost 100% in mice homozygous for the Spry2 allele alone

growth/size/body
supernumerary teeth ( J:119280 )
• frequency of diastema tooth formation is reduced to 60% compared to almost 100% in mice homozygous for the Spry2 allele alone

skeleton
supernumerary teeth ( J:119280 )
• frequency of diastema tooth formation is reduced to 60% compared to almost 100% in mice homozygous for the Spry2 allele alone




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory