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Allele Symbol Allele Name Allele ID |
Pafah1b2tm1Arai targeted mutation 1, Hiroyuki Arai MGI:2655809 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at 5 weeks of age, mutant testes weigh ~40% less than those of wild-type mice
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• at 5 weeks of age, mutant testes weigh ~40% less than those of wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at 5 weeks of age, some double mutant germ cells appear to be detached from the Sertoli cells
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• at 5 weeks of age, double mutant males show a significant reduction of spermatogenic cells, especially after the pachytene spermatocyte stage; round spermatids are significantly reduced in number, while elongated spermatids are rare
• at later ages, early germ cell stages are more severely affected, leading to pronounced depletion of spermatocytes and spermatogonia
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• no spermatozoa are detected in the epididymis at 5 weeks of age
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• at 5 weeks of age, double mutant testes display increased apoptosis of spermatogenic cells, as shown by TUNEL staining
• the majority of cells undergoing apoptosis are spermatocytes
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• at 5 weeks of age, double mutant males show a ~50% reduction in seminiferous tubule diameter relative to wild-type males
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• at 5 weeks of age, double mutant testes weigh ~65% less than those of wild-type mice
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• double mutant males exhibit defects in several aspects of spermatogenesis, including severe degeneration of primary spermatocytes as well as degeneration of meiotically dividing spermatocytes and elongating spermatids
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• at 5 weeks of age, the few remaining spermatids exhibit deformed nuclei
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• double mutant males are infertile
• in contrast, double mutant females are fertile
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• at 5 weeks of age, double mutant males show a ~50% reduction in seminiferous tubule diameter relative to wild-type males
|
|
|
|
|
|
• at 5 weeks of age, double mutant testes weigh ~65% less than those of wild-type mice
|
|
|
• at 5 weeks of age, some double mutant germ cells appear to be detached from the Sertoli cells
|
|
|
• at 5 weeks of age, the few remaining spermatids exhibit deformed nuclei
|
|
|
• at 5 weeks of age, double mutant males show a significant reduction of spermatogenic cells, especially after the pachytene spermatocyte stage; round spermatids are significantly reduced in number, while elongated spermatids are rare
• at later ages, early germ cell stages are more severely affected, leading to pronounced depletion of spermatocytes and spermatogonia
|
|
|
• no spermatozoa are detected in the epididymis at 5 weeks of age
|
|
|
• at 5 weeks of age, double mutant testes display increased apoptosis of spermatogenic cells, as shown by TUNEL staining
• the majority of cells undergoing apoptosis are spermatocytes
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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