Phenotypes associated with this allele

• Allele Symbol: Gdf7^tm1Tmj
• Allele Name: targeted mutation 1, Thomas M Jessell
• Allele ID: MGI:2653921
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gdf7^tm1Tmj/Gdf7^tm1Tmj	involves: 129	MGI:3575011
hm2	Gdf7^tm1Tmj/Gdf7^tm1Tmj	involves: 129P2/OlaHsd * C57BL/6	MGI:3575010

Genotype
MGI:3575011

hm1

• Allelic Composition: Gdf7^tm1Tmj/Gdf7^tm1Tmj
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

hydrocephaly ( J:50972 )

• incomplete penetrance; 20% of homozygous animals exhibited phenotype on an inbred 129 genetic background

dilated fourth ventricle ( J:50972 )

• at postnatal day 15, 25% of mutant brains showed marked dilation of the lateral ventricles with no obvious defects in the morphology of the cerebellum or the cerebral cortex

dilated lateral ventricle ( J:50972 )

• by postnatal day 40 severe hydroencephaly associated with dilation of the fourth and left ventricles was observed

abnormal cerebral cortex morphology ( J:50972 )

• in all affected brains the cerebral cortex was thinned and the hippocampus was displaced dorsally, although the cellular organization of the cerebellum and the cerebral cortex was grossly normal

abnormal dorsal interneuron 1 morphology ( J:50972 )

• the number of dorsal D1A commissural interneurons in E12.5, E13.5, and E14.5 spinal cord was reduced by ~92% compared with wild-type embryos, with no apparent change in the number of D1B neurons

Genotype
MGI:3575010

hm2

• Allelic Composition: Gdf7^tm1Tmj/Gdf7^tm1Tmj
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

nervous system

hydrocephaly ( J:50972 )

• incomplete penetrance; 37% of homozygous mice exhibited this phenotype on a mixed 129P2/Ola Hsd and C57BL/6 genetic background

dilated fourth ventricle ( J:50972 )

• by postnatal day 40 severe hydroencephaly associated with dilation of the fourth and left ventricles was observed

dilated lateral ventricle ( J:50972 )

• at postnatal day 15, 25% of mutant brains showed marked dilation of the lateral ventricles with no obvious defects in the morphology of the cerebellum or the cerebral cortex

abnormal cerebral cortex morphology ( J:50972 )

• in all affected brains the cerebral cortex was thinned and the hippocampus was displaced dorsally, although the cellular organization of the cerebellum and the cerebral cortex was grossly normal

abnormal dorsal interneuron 1 morphology ( J:50972 )

• the number of dorsal D1A commissural interneurons in E12.5, E13.5, and E14.5 spinal cord was reduced by about 92% compared with wild-type embryos, with no apparent change in the number of D1B neurons