Gdf7^tm1Tmj
Targeted Allele Detail

Summary

• Symbol: Gdf7^tm1Tmj
• Name: growth differentiation factor 7; targeted mutation 1, Thomas M Jessell
• MGI ID: MGI:2653921
• Synonyms: Gdf7-, Gdf7^m1
• Gene: Gdf7 Location: Chr12:8347918-8351954 bp, - strand Genetic Position: Chr12, 3.85 cM
• Alliance: Gdf7^tm1Tmj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50972
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin resistance cassette replaced the exon that encodes half of the propeptide domain and the entire mature carboxy terminal domain. In situ hybridization studies did not detect transcript in neural tube roof plates from homozygous mutant embryos. (J:50972)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gdf7 Mutation: 16 strains or lines available

References

• Original: J:50972 Lee KJ, et al., Neuronal patterning by BMPs: a requirement for GDF7 in the generation of a discrete class of commissural interneurons in the mouse spinal cord. Genes Dev. 1998 Nov 1;12(21):3394-407
• All: 1 reference(s)