Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp1r15atm1Dron mutation
(0 available);
any
Ppp1r15a mutation
(22 available)
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cellular
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• persistent repression of protein synthesis in E13.5 embryonic fibroblasts in response to ER- or oxidative- stress
• lack of protein synthesis resulted in impaired translation of stress-induced proteins and impaired expression of stress-induced genes
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp1r15atm1Dron mutation
(0 available);
any
Ppp1r15a mutation
(22 available)
Ppp1r15btm1Dron mutation
(0 available);
any
Ppp1r15b mutation
(14 available)
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Ppp1r15atm1Dron/Ppp1r15atm1Dron Ppp1r15btm1Dron/Ppp1r15btm1Dron embryos fail to develop past the preimplantation period
mortality/aging
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• embryos do not develop beyond pre-implantation stages
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp1r15atm1Dron mutation
(0 available);
any
Ppp1r15a mutation
(22 available)
Ppp1r15btm1Dron mutation
(0 available);
any
Ppp1r15b mutation
(14 available)
|
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp1r15atm1Dron mutation
(0 available);
any
Ppp1r15a mutation
(22 available)
Ppp1r15btm1Dron mutation
(0 available);
any
Ppp1r15b mutation
(14 available)
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mortality/aging
N |
• mice survive into adulthood
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif2s1tm1Rjk mutation
(1 available);
any
Eif2s1 mutation
(57 available)
Ppp1r15atm1Dron mutation
(0 available);
any
Ppp1r15a mutation
(22 available)
Ppp1r15btm1Dron mutation
(0 available);
any
Ppp1r15b mutation
(14 available)
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mortality/aging
N |
• mice survive until E17.5
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growth/size/body
N |
• unlike Ppp1r15btm1Dron homozygotes, mice are of normal size at E17.5
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