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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ikbkbtm2.1Cgn
targeted mutation 2.1, University of Cologne
MGI:2652652
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ikbkbtm2.1Cgn/Ikbkbtm2.1Cgn involves: C57BL/6 MGI:3851692
cn2
 		Cd19tm1(cre)Cgn/Cd19+
Ikbkbtm2Cgn/Ikbkbtm2.1Cgn 		involves: 129P2/OlaHsd * C57BL/6 MGI:3851694
cn3
 		Ikbkbtm2Cgn/Ikbkbtm2.1Cgn
Tg(Cd4-cre)1Cwi/0 		involves: C57BL/6 * DBA/2 MGI:2679030


Genotype
MGI:3851692
hm1
Allelic
Composition		 Ikbkbtm2.1Cgn/Ikbkbtm2.1Cgn
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkbtm2.1Cgn mutation (0 available); any Ikbkb mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interleukin-6 secretion ( J:79132 )
• TNF-mediated IL-6 production is abolished in embryonic cells




Genotype
MGI:3851694
cn2
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Ikbkbtm2Cgn/Ikbkbtm2.1Cgn
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (56 available)
Ikbkbtm2.1Cgn mutation (0 available); any Ikbkb mutation (54 available)
Ikbkbtm2Cgn mutation (1 available); any Ikbkb mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased mature B cell number ( J:79132 )
• there is a 2- to 4- fold reduction in the number of mature recirculating B cells found in the bone marrow
• the IgMlowIgD+ mature B cell population is strongly diminished in the spleen by 3- to 4- fold
• B cell numbers in the lymph nodes are also strongly reduced
decreased B-1 B cell number ( J:79132 )
• B-1 B cell numbers are strongly decreased in the peritoneum cavity
decreased follicular B cell number ( J:79132 )
• follicular B cells are the most diminished B cell population in the spleen
decreased marginal zone B cell number ( J:79132 )
• marginal zone B cell numbers are reduced about 4-fold

immune system
decreased mature B cell number ( J:79132 )
• there is a 2- to 4- fold reduction in the number of mature recirculating B cells found in the bone marrow
• the IgMlowIgD+ mature B cell population is strongly diminished in the spleen by 3- to 4- fold
• B cell numbers in the lymph nodes are also strongly reduced
decreased B-1 B cell number ( J:79132 )
• B-1 B cell numbers are strongly decreased in the peritoneum cavity
decreased follicular B cell number ( J:79132 )
• follicular B cells are the most diminished B cell population in the spleen
decreased marginal zone B cell number ( J:79132 )
• marginal zone B cell numbers are reduced about 4-fold




Genotype
MGI:2679030
cn3
Allelic
Composition		 Ikbkbtm2Cgn/Ikbkbtm2.1Cgn
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkbtm2.1Cgn mutation (0 available); any Ikbkb mutation (54 available)
Ikbkbtm2Cgn mutation (1 available); any Ikbkb mutation (54 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD4-positive, alpha-beta T cell number ( J:85810 )
• CD4+ T cells are reduced by about 20% in the periphery
decreased CD8-positive, alpha-beta T cell number ( J:85810 )
• CD8+ T cells are reduced by about 50% in the periphery
abnormal humoral immune response ( J:85810 )
• the antibody response to the T-dependent antigen NP-CG is delayed
decreased IgE level ( J:85810 )
• slight reduction in serum concentration of IgE following immunization with the T-dependent antigen NP-CG

hematopoietic system
decreased CD4-positive, alpha-beta T cell number ( J:85810 )
• CD4+ T cells are reduced by about 20% in the periphery
decreased CD8-positive, alpha-beta T cell number ( J:85810 )
• CD8+ T cells are reduced by about 50% in the periphery
decreased IgE level ( J:85810 )
• slight reduction in serum concentration of IgE following immunization with the T-dependent antigen NP-CG




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory