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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Lck-Prnp)33Cwe
transgene insertion 33, Charles Weissmann
MGI:2652525
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Prnptm1Cwe/Prnptm1Cwe
Tg(Lck-Prnp)33Cwe/0 		involves: 129S7/SvEvBrd * C57BL/6 MGI:4821407


Genotype
MGI:4821407
cx1
Allelic
Composition		 Prnptm1Cwe/Prnptm1Cwe
Tg(Lck-Prnp)33Cwe/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm1Cwe mutation (37 available); any Prnp mutation (143 available)
Tg(Lck-Prnp)33Cwe mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
thymus hypoplasia ( J:129512 )
• at 10.5 weeks
increased CD8-positive, alpha-beta T cell number ( J:129512 )
• the number of immature CD8+ T cells is increased compared to in wild-type mice

hematopoietic system
thymus hypoplasia ( J:129512 )
• at 10.5 weeks
increased CD8-positive, alpha-beta T cell number ( J:129512 )
• the number of immature CD8+ T cells is increased compared to in wild-type mice

endocrine/exocrine glands
thymus hypoplasia ( J:129512 )
• at 10.5 weeks




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory