Phenotypes associated with this allele

• Allele Symbol: Ncoa6^tm1Pera
• Allele Name: targeted mutation 1, Per Antonson
• Allele ID: MGI:2450859
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ncoa6^tm1Pera/Ncoa6^tm1Pera	involves: 129X1/SvJ * C57BL/6	MGI:2450869

Genotype
MGI:2450869

hm1

• Allelic Composition: Ncoa6^tm1Pera/Ncoa6^tm1Pera
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:81818 )

• no surviving embryos past day E14.5

embryo

abnormal placenta morphology ( J:81818 )

• necrosis at maternal-embryonal interface

abnormal placenta vasculature ( J:81818 )

• collapse of blood vessels at border of spongiotrophoblast and labyrinthine domains

abnormal placental labyrinth vasculature morphology ( J:81818 )

• at day E13.5 labyrinthine layer appears less vascularized

decreased spongiotrophoblast size ( J:81818 )

• reduced spongiotrophoblast layer

cardiovascular system

abnormal placenta vasculature ( J:81818 )

• collapse of blood vessels at border of spongiotrophoblast and labyrinthine domains

abnormal placental labyrinth vasculature morphology ( J:81818 )

• at day E13.5 labyrinthine layer appears less vascularized

trabecula carnea hypoplasia ( J:81818 )

disorganized myocardium ( J:81818 )

thin myocardium ( J:81818 )

thin ventricular wall ( J:81818 )

nervous system

delayed brain development ( J:81818 )

dilated third ventricle ( J:81818 )

abnormal hypothalamus morphology ( J:81818 )

• underdeveloped hypothalamus

small thalamus ( J:81818 )

• underdeveloped thalamus

absent olfactory bulb ( J:81818 )

decreased neuron number ( J:81818 )

• reduced number of differentiated neurons in neopallial cortex

muscle

trabecula carnea hypoplasia ( J:81818 )

disorganized myocardium ( J:81818 )

thin myocardium ( J:81818 )