Ncoa6^tm1Pera
Targeted Allele Detail

Summary

• Symbol: Ncoa6^tm1Pera
• Name: nuclear receptor coactivator 6; targeted mutation 1, Per Antonson
• MGI ID: MGI:2450859
• Synonyms: Rap250^-
• Gene: Ncoa6 Location: Chr2:155232585-155315741 bp, - strand Genetic Position: Chr2, 77.26 cM, cytoband H2
• Alliance: Ncoa6^tm1Pera page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81818
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exons 7 and 8 with a neomycin resistance cassette via homologous recombination, resulting in deletion of the nuclear receptor box and transactivation domain. Absence of gene expression was verified by RT-PCR analysis of fibroblasts derived from homozygous mutant embryos. (J:81818)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ncoa6 Mutation: 100 strains or lines available

References

• Original: J:81818 Antonson P, et al., Inactivation of the nuclear receptor coactivator RAP250 in mice results in placental vascular dysfunction. Mol Cell Biol. 2003 Feb;23(4):1260-8
• All: 1 reference(s)