All Phenotypes Mfn1<tm1Dcc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mfn1^tm1Dcc
targeted mutation 1, David C Chan
MGI:2450304

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mfn1^tm1Dcc/Mfn1^tm1Dcc	involves: 129S/SvEv	MGI:3578769
cn2	Mfn1^tm1Dcc/Mfn1^tm2Dcc	involves: 129 * 129S4/SvJaeSor * Black Swiss	MGI:3779082
cn3	Mfn1^tm1Dcc/Mfn1^tm2Dcc Mfn2^tm3Dcc/Mfn2⁺	involves: 129 * 129S4/SvJaeSor * Black Swiss	MGI:3779090
cn4	Mfn1^tm1Dcc/Mfn1^tm2Dcc Mfn2^tm1Dcc/Mfn2^tm3Dcc Tg(Pcp2-cre)2Mpin/0	involves: 129 * 129S4/SvJaeSor * Black Swiss	MGI:3779091
cn5	Mfn1^tm1Dcc/Mfn1^tm2Dcc Tg(EIIa-cre)C5379Lmgd/0	involves: 129 * 129S4/SvJaeSor * Black Swiss * FVB/N	MGI:3779085
cn6	Meox2^tm1(cre)Sor/Meox2⁺ Mfn1^tm1Dcc/Mfn1^tm2Dcc	involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss	MGI:3779086
cn7	Meox2^tm1(cre)Sor/Meox2⁺ Mfn1^tm1Dcc/Mfn1^tm2Dcc Mfn2^tm3Dcc/Mfn2⁺	involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss	MGI:3779087
cn8	Meox2^tm1(cre)Sor/Meox2⁺ Mfn1^tm1Dcc/Mfn1^tm2Dcc Mfn2^tm1Dcc/Mfn2^tm3Dcc	involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss	MGI:3779088
cx9	Mfn1^tm1Dcc/Mfn1^tm1Dcc Mfn2^tm1Dcc/Mfn2^tm1Dcc	involves: 129S/SvEv	MGI:3578771

Allelic Composition	Mfn1^tm1Dcc/Mfn1^tm1Dcc
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mfn1^tm1Dcc mutation (0 available); any Mfn1 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:81438 )

• frequency of homozygous embryos normal up to E10.5

• 20% of homozygotes resorbed at E11.5

• 86% of homozygotes resorbed at E12.5

embryo

embryonic growth retardation ( J:81438 )

• observed at E8.5

• often deformed as well

decreased embryo size ( J:81438 )

• embryos significantly smaller than controls at E8.5

cellular

abnormal mitochondrial morphology ( J:81438 )

• fragmented mitochondria

abnormal mitochondrial physiology ( J:81438 )

• mitochondrial fusion reduced

• mobility severely affected

• individual mitochondria functionally defective

growth/size/body

embryonic growth retardation ( J:81438 )

• observed at E8.5

• often deformed as well

decreased embryo size ( J:81438 )

• embryos significantly smaller than controls at E8.5

Allelic Composition	Mfn1^tm1Dcc/Mfn1^tm2Dcc
Genetic Background	involves: 129 * 129S4/SvJaeSor * Black Swiss

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal mitochondrial morphology ( J:132329 )

• fibroblast derived from mutant animals exhibit Cre-dependent mitochondrial fragmentation

• loss of mtDNA nucleoids from a significant fraction of mitochondria

Allelic Composition	Mfn1^tm1Dcc/Mfn1^tm2Dcc Mfn2^tm3Dcc/Mfn2⁺
Genetic Background	involves: 129 * 129S4/SvJaeSor * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mfn1^tm1Dcc mutation (0 available); any Mfn1 mutation (44 available)
Mfn1^tm2Dcc mutation (2 available); any Mfn1 mutation (44 available)
Mfn2^tm3Dcc mutation (2 available); any Mfn2 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:132329 )

• normal cerebella containing a uniform, unbroken Purkinje cell monolayer similar to that in wild-type mice at 9-week-old

Allelic Composition	Mfn1^tm1Dcc/Mfn1^tm2Dcc Mfn2^tm1Dcc/Mfn2^tm3Dcc Tg(Pcp2-cre)2Mpin/0
Genetic Background	involves: 129 * 129S4/SvJaeSor * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mfn1^tm1Dcc mutation (0 available); any Mfn1 mutation (44 available)
Mfn1^tm2Dcc mutation (2 available); any Mfn1 mutation (44 available)
Mfn2^tm1Dcc mutation (0 available); any Mfn2 mutation (26 available)
Mfn2^tm3Dcc mutation (2 available); any Mfn2 mutation (26 available)
Tg(Pcp2-cre)2Mpin mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

Purkinje cell degeneration ( J:132329 )

• Purkinje cell death in 9 weeks-old mutant mice cerebella

abnormal Purkinje cell dendrite morphology ( J:132329 )

• Purkinje cell dendrite attenuation in 9 weeks-old mutant mice cerebella

cellular

abnormal respiratory electron transport chain ( J:132329 )

• decreased cytochrome C oxidase activity and increased succinate dehydrogenase activity in Purkinje cells of 9-weeks-old mutant mice indicating the electron transport chain dysfunction in mitochondria

Allelic Composition	Mfn1^tm1Dcc/Mfn1^tm2Dcc Tg(EIIa-cre)C5379Lmgd/0
Genetic Background	involves: 129 * 129S4/SvJaeSor * Black Swiss * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:132329 )

• embryos die during mid-gestation similar to Mfn1^tm1Dcc homozygous embryos

Allelic Composition	Meox2^tm1(cre)Sor/Meox2⁺ Mfn1^tm1Dcc/Mfn1^tm2Dcc
Genetic Background	involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:132329 )

• mutant mice survive through adulthood with no obvious defects

• both males and females are fully fertile and healthy to at least one year

Allelic Composition	Meox2^tm1(cre)Sor/Meox2⁺ Mfn1^tm1Dcc/Mfn1^tm2Dcc Mfn2^tm3Dcc/Mfn2⁺
Genetic Background	involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2^tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
Mfn1^tm1Dcc mutation (0 available); any Mfn1 mutation (44 available)
Mfn1^tm2Dcc mutation (2 available); any Mfn1 mutation (44 available)
Mfn2^tm3Dcc mutation (2 available); any Mfn2 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:132329 )

• invariably die on P0

Allelic Composition	Meox2^tm1(cre)Sor/Meox2⁺ Mfn1^tm1Dcc/Mfn1^tm2Dcc Mfn2^tm1Dcc/Mfn2^tm3Dcc
Genetic Background	involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2^tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
Mfn1^tm1Dcc mutation (0 available); any Mfn1 mutation (44 available)
Mfn1^tm2Dcc mutation (2 available); any Mfn1 mutation (44 available)
Mfn2^tm1Dcc mutation (0 available); any Mfn2 mutation (26 available)
Mfn2^tm3Dcc mutation (2 available); any Mfn2 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:132329 )

• invariably die on P0

Allelic Composition	Mfn1^tm1Dcc/Mfn1^tm1Dcc Mfn2^tm1Dcc/Mfn2^tm1Dcc
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mfn1^tm1Dcc mutation (0 available); any Mfn1 mutation (44 available)
Mfn2^tm1Dcc mutation (0 available); any Mfn2 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality ( J:81438 )

• death occurs earlier than when either allele is singly homozygous

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