Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2tm3(Erbb2)Mul mutation
(0 available);
any
Erbb2 mutation
(59 available)
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muscle
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• this reduced number had no apparent effect on the motor capability of the animals
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• this reduced number had no apparent effect on the motor capability of the animals
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nervous system
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• this reduced number had no apparent effect on the motor capability of the animals
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• this reduced number had no apparent effect on the motor capability of the animals
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2tm3(Erbb2)Mul mutation
(0 available);
any
Erbb2 mutation
(59 available)
Tg(Ckmm-cre)5Khn mutation
(4 available)
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mortality/aging
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• early mortality is observed in severely affected mutants
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behavior/neurological
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• progressive with age, animals rest on abdomen instead of limbs
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• mutants often maintain limbs in an abnormal posture, progressing from a flexor to an extensor posture
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craniofacial
growth/size/body
muscle
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• an increase in apoptosis is observed in mutant myoblasts infected with adenoviral-cre (to completely obliterate expression) during induced differentiation
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• 2 weeks after a muscle crush injury in the tibialis anterior, muscle fibers that have regenerated are not continuous and are interspersed with encapsulated cellular debris
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skeleton
nervous system
cellular
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• an increase in apoptosis is observed in mutant myoblasts infected with adenoviral-cre (to completely obliterate expression) during induced differentiation
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2tm1Mll mutation
(1 available);
any
Erbb2 mutation
(59 available)
Erbb2tm3(Erbb2)Mul mutation
(0 available);
any
Erbb2 mutation
(59 available)
Tg(ACTA1-cre)1Mll mutation
(0 available)
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behavior/neurological
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• when placed on a slippery surface, mutants are unable to position their limbs properly
• mutants exhibit spastic movements
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• abnormal hindlimb extension reflexes
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muscle
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• initial contact between sensory Ia afferent neurons and myotubes occurs but subsequent development of muscle spindles is impaired
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• absence of muscle spindles
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nervous system
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• initial contact between sensory Ia afferent neurons and myotubes occurs but subsequent development of muscle spindles is impaired
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• absence of muscle spindles
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• synapses at neuromuscular junctions contain reduced numbers of acetylcholine receptors
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• mutants exhibit reduced synaptic transmission at neuromuscular junctions; mepc amplitudes are reduced by about 15% compared to wild-type
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Analysis Tools