Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Opn4tm1Yau mutation
(0 available);
any
Opn4 mutation
(33 available)
Opn4tm4(DTA)Saha mutation
(0 available);
any
Opn4 mutation
(33 available)
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vision/eye
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• only 17.1% of retinal ganglion cells expressing melanopsin are present compared to wild-type controls
• there are fewer fiber terminals from the retinal ganglion cells reach into the suprachiasmatic nucleus, the intergeniculate leaflet, and the olivary pretectal nucleus
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nervous system
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• few fibers innervate the SCN from the retinal ganglion cells
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• only 17.1% of retinal ganglion cells expressing melanopsin are present compared to wild-type controls
• there are fewer fiber terminals from the retinal ganglion cells reach into the suprachiasmatic nucleus, the intergeniculate leaflet, and the olivary pretectal nucleus
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Opn4tm1.1(cre)Saha mutation
(0 available);
any
Opn4 mutation
(33 available)
Opn4tm1Yau mutation
(0 available);
any
Opn4 mutation
(33 available)
Pou4f2tm4(DTA)Whk mutation
(1 available);
any
Pou4f2 mutation
(7 available)
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nervous system
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• and olivary pretectal nucleus (OPN) projections are eliminated, compared to controls
• no fibres are observed in the shell of the OPN
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• innervation of the intergeniculate nucleus (IGL) is markedly reduced
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• only 200 M1 (Pou4f2-negative) ipRGCs (intrinsically photosensitive retinal ganglion cells) are detected in the retinas; these remaining fibers innervated the SCN to the same extent as control Pou4f2tm2.1Nat/+ ;Opn4tm1.1(cre)Saha/+ animals
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vision/eye
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• only 200 M1 (Pou4f2-negative) ipRGCs (intrinsically photosensitive retinal ganglion cells) are detected in the retinas; these remaining fibers innervated the SCN to the same extent as control Pou4f2tm2.1Nat/+ ;Opn4tm1.1(cre)Saha/+ animals
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Opn1mwtm1(OPN1LW)Nat mutation
(1 available);
any
Opn1mw mutation
(4 available)
Opn4tm1Yau mutation
(0 available);
any
Opn4 mutation
(33 available)
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vision/eye
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• mice learn to swim toward higher radiance target, green vs red or dim red vs brighter red
• mice no longer distinguish between green and red targets at a higher green radiance level than do mice homozygous only for Opn1mwtm1(OPN1LW)Nat
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnga3tm1Biel mutation
(0 available);
any
Cnga3 mutation
(26 available)
Gnat1tm1Clma mutation
(1 available);
any
Gnat1 mutation
(20 available)
Opn4tm1Yau mutation
(0 available);
any
Opn4 mutation
(33 available)
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behavior/neurological
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• triple mutants essentially show no pupillary reflex in response to intense exposure of light at 480 nm, monochromatic light at other wavelengths (360-660 nm) or intense white light
• on close scrutiny, 2 out of 6 triple mutants displayed a small, very transient pupil constriction in response to bright 480-nm light; however, this was not consistently observed on repeated stimulus trials with extensive dark adaptation (up to 3 days) in between
• in contrast, triple mutants exhibit maximum pupil constriction in response to carbachol (a parasympathetic agonist)
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• actograms of wheel running under a 16/8-h light/dark cycle showed that triple mutants free-run with a period of less than 24 hours
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• triple homozygotes fail to entrain to light/dark cycles and show no masking response to light
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vision/eye
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• triple homozygotes display normal retinal morphology and thickness relative to wild-type mice
• also, triple mutants show normal abundance and central connectivity of melanopsin-expressing retinal ganglion cells in brain
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• triple mutants essentially show no pupillary reflex in response to intense exposure of light at 480 nm, monochromatic light at other wavelengths (360-660 nm) or intense white light
• on close scrutiny, 2 out of 6 triple mutants displayed a small, very transient pupil constriction in response to bright 480-nm light; however, this was not consistently observed on repeated stimulus trials with extensive dark adaptation (up to 3 days) in between
• in contrast, triple mutants exhibit maximum pupil constriction in response to carbachol (a parasympathetic agonist)
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Analysis Tools