Analysis Tools|
Allele Symbol Allele Name Allele ID |
Smad4E6sad Exon 6 splice acceptor deletion MGI:2449701 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no homozygote offspring result from heterozygote crosses
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• embryos are growth restricted at E7.5
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• embryos are growth restricted at E7.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 40% of mice have died by 20 months of age due complications from intestinal tumors
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• 10% of mice exhibit polyps by 9 months of age in the small intestine
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• polyps occur in mice over 15 months of age with an incidence of up to 22%
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• 100% of mice have hyperplastic polyps in the stomach at 9 months of age
• tumors increase in size from an average of 3 mm in size at 9 months to 8 mm in size at 18 months
• in the pyloric/duodenal transition area, 100% of mice over 12 months in age have polyps with some exhibiting a carpet of polyps
• polyps were hyperplastic with branching villi and occasionally have serrated edges
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• tumors ranging in size from 1 to 5 mm are found immediately distal to the pyloric/duodenal transition in mice over 16 months of age
• tumors are heterogeneous with 30% being serrated adenomas
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• two out of fifteen mice have small hyperplastic lesions present in the gastric mucosa
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• tumors ranging in size from 1 to 5 mm are found immediately distal to the pyloric/duodenal transition in mice over 16 months of age
• tumors are heterogeneous with 30% being serrated adenomas
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• some of the polyps found distal of the pyloric/duodenal transition have gastric surface epithelial cells
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• two out of fifteen mice have small hyperplastic lesions present in the gastric mucosa
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Background Sensitivity: all mice have died by 8 months of age due to complications arising from intestinal tumors
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• Background Sensitivity: in two of seven mice, adenocarcinomas with invasion of the muscolaris mucosa are observed
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• Background Sensitivity: by 7 months of age, mice present with an average of 20 tumors along the intestinal tract
• Background Sensitivity: tumors are mainly villous or tubulovillous adenomas with foci of severe dysplasia
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• Background Sensitivity: in 100% of mice by 7 months of age
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• Background Sensitivity: in two of seven mice, adenocarcinomas with invasion of the muscolaris mucosa are observed
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• Background Sensitivity: by 7 months of age, mice present with an average of 20 tumors along the intestinal tract
• Background Sensitivity: tumors are mainly villous or tubulovillous adenomas with foci of severe dysplasia
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Background Sensitivity: all mice have died by 3 months of age due to complications arising from intestinal tumors
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• Background Sensitivity: numerous microadenomas in the upper gastrointestinal tract are present upon microscopic inspection
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• Background Sensitivity: numerous microadenomas in the upper gastrointestinal tract are present upon microscopic inspection
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• Background Sensitivity: an average of 60 tumors per mouse by 6 weeks of age
• Background Sensitivity: polyps are either sessile or villous with mild to severe dysplasia
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• Background Sensitivity: found in 25% of 3-6 week old mice
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• Background Sensitivity: found in moribund mice
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• Background Sensitivity: found in moribund mice
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• Background Sensitivity: found in moribund mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Phenotypic analysis of the compound in cis Apctm2Rfo/Apc+ Smad4E6sad/Smad4+ mouse model
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• unlike in Apctm2Rfo heterozygotes, mice develop multiple gastro-intestinal tumors and adenomatous polyps
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• similar to in Apctm2Rfo heterozygotes
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• unlike in Apctm2Rfo heterozygotes, mice develop multiple gastro-intestinal tumors and adenomatous polyps
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• similar to in Apctm2Rfo heterozygotes
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• similar to in Apctm2Rfo heterozygotes
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/30/2025 MGI 6.24 |
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