Analysis Tools
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice treated with 0.5 mg/ml doxycycline for 5 days followed by 0.25 mg/ml doxycycline for 5 days starting at 3 weeks of age do not display abnormalities in calcium or phosphate homeostasis
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• hypoxic primary tubular epithelial cells from doxycycline treated mice fails to migrate unlike similarly treated cells from Hif1atm3Rsjo/Hif1atm3Rsjo Gt(ROSA)26Sortm1(rtTA)Awu/Gt(ROSA)26Sor+ mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice induced with doxycycline show neither an amelioration nor aggravation of the lung disease phenotype that is seen in conditional Nedd4l knock-out mice
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• lungs from doxycycline treated mice show hallmarks of interstitial pulmonary fibrosis
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit an overall mortality of 70% at 4 months on doxycycline
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• mice induced with doxycycline exhibit mortality associated with severe weight loss and hypoxia after approximately 3 months on doxycycline, resulting in an overall mortality of 70% at 4 months on doxycycline
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• mice show severe weight loss after approximately 3 months on doxycycline
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• bronchoalveolar lavage fluid shows activated macrophages and total cells, macrophages, neutrophils, and cytokines such as interleukin-1beta, keratinocyte-derived chemokine, and interleukin-13 are increased from 2-3 months on doxycycline
• inflammatory markers including neutrophils, and levels of IL-13 and IL-1beta in bronchoalveolar lavage fluid are reduced in lungs of pirfenidone-treated mice
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• lungs from doxycycline treated mice show traction bronchiectasis
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• lungs of doxycycline induced mice exhibit epithelial remodeling of the peripheral airways characterized by a decrease in club cells and increase in ciliated cells and goblet cells in distal and terminal airways and increase in production of Muc5b in epithelial cells along the tracheobronchial tree extending into terminal airways and in honeycomb-like cysts
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• lungs from doxycycline treated mice show hypertrophy of alveolar type 2 cells
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• lungs from doxycycline treated mice show hallmarks of interstitial pulmonary fibrosis, including reticular opacities, traction bronchiectasis, and honeycombing-like cysts with spatially heterogenous distribution in peripheral regions of the lung
• lungs from doxycycline treated mice show areas of patchy fibrosis of the alveolar interstitium associated with inflammatory infiltrates, alpha smooth muscle actin-positive fibroblast foci-like structures, increased collagen deposition, septal wall thickening, hypertrophy of alveolar type 2 cells, subpleural microscopic honeycombing-like cysts, and Muc5b-positive material within fibrotic areas of peripheral airspaces
• mice treated with pirfenidone for 4 weeks two months after tamoxifen induction, when lungs show first signs of fibrotic remodeling, exhibit reduced fibrosis
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• increase in ENaC activity is associated with reduced airway surface liquid height and reduced mucociliary transport velocity on primary airway cultures
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• pulmonary function testing shows progressive restriction with a 45% decrease in static compliance at 4 months on doxycycline
• mice treated with pirfenidone for 4 weeks two months after tamoxifen induction show improved static compliance
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• transepithelial bioelectric measurements preformed after 2 weeks of doxycycline induction show an approximately 3-fold increase in amiloride-sensitive epithelial Na+ channel (ENaC)-mediated Na+ currents in freshly excised airway tissues
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• bronchoalveolar lavage fluid shows activated macrophages and total cells, macrophages, neutrophils, and cytokines such as interleukin-1beta, keratinocyte-derived chemokine, and interleukin-13 are increased from 2-3 months on doxycycline
• inflammatory markers including neutrophils, and levels of IL-13 and IL-1beta in bronchoalveolar lavage fluid are reduced in lungs of pirfenidone-treated mice
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• lungs from doxycycline treated mice show traction bronchiectasis
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• lungs of doxycycline treated mice show elevated levels of active TGFbeta
• mice treated with pirfenidone for 4 weeks two months after tamoxifen induction show decreased concentrations of active TGFbeta in lungs
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| idiopathic pulmonary fibrosis | DOID:0050156 | J:292026 | ||
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal motor coordination and spatial reference memory acquisition in a Morris Water maze
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• mice exhibit impaired spatial reversal learning compared with control mice
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• mice exhibit a small impairment in spatial working memory in an enclosed T maze compared with control mice
• less so than Grin2btm1Mony/Grin2btm1Mony Tg(Camk2a-cre)1Gsc mice
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• less so than Grin2btm1Mony/Grin2btm1Mony Tg(Camk2a-cre)1Gsc mice
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• less so than Grin2btm1Mony/Grin2btm1Mony Tg(Camk2a-cre)1Gsc mice
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• in response to the Grin2b antagonist ifenprodil, mice fail to exhibit a strong reduction in NMDA excitatory postsynaptic currents and faster decay kinetics compared with control mice
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• in response to the Grin2b antagonist ifenprodil, mice fail to exhibit a strong reduction in NMDA excitatory postsynaptic currents and faster decay kinetics compared with control mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• induced by pentylenetetrazil in mice treated with doxycycline treatment between conception and P21 or not treated with doxycycline at all
• induced by pentylenetetrazil compared with Gabrg2tm2Spet heterozygotes
• doxycycline treatment between conception and P21 increased the time to first clonic seizure compared with mice not treated with doxycycline
• however, no seizure kindling effect is observed
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• induced by pentylenetetrazil in mice treated with doxycycline treatment between conception and P21 or not treated with doxycycline at all
• induced by pentylenetetrazil compared with Gabrg2tm2Spet heterozygotes
• doxycycline treatment between conception and P21 increased the time to first clonic seizure compared with mice not treated with doxycycline
• however, no seizure kindling effect is observed
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• complete loss of NMDAR-mediated long term potential at dentate gyrus synapses
• however, long term potentiation at Schaffer collateral-CA1 synapses is similar to wild-type mice despite residual Cre activity in CA1 pyramidal cells
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• mice exhibit impaired spatial working memory but normal spatial reference memory in a 3 from 6 radial arm maze task
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Background Sensitivity: in doxycycline-treated mice raised by FVB/J
• however, doxycycline-treated mice raised by C57BL/6J dams exhibit normal white adipose tissue weight
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• Background Sensitivity: in doxycycline-treated mice raised by FVB/J
• however, doxycycline-treated mice raised by C57BL/6J dams exhibit normal white adipose tissue weight
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• Background Sensitivity: visceral, epididymal and subcutaneous white adipose tissue in doxycycline-treated mice raised by FVB/J
• however, doxycycline-treated mice raised by C57BL/6J dams exhibit normal white adipose tissue weight
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• Background Sensitivity: in doxycycline-treated mice raised by FVB/J
• however, doxycycline-treated mice raised by C57BL/6J dams exhibit normal leptin levels
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• Background Sensitivity: in doxycycline-treated mice raised by FVB/J
• however, doxycycline-treated mice raised by C57BL/6J dams exhibit normal leptin levels
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• Background Sensitivity: in an elevated plus maze and open field test, doxycycline-treated mice raised by FVB/J dams exhibit increased anxiety-related behaviors compared with similarly fostered control mice
• however, doxycycline-treated mice fostered by C57BL/6J dams exhibit normal anxiety
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• doxycycline-treated mice raised by C57BL/6J dams exhibit decreased total distance traveled in an open field compared with control mice and doxycycline-treated mice raised by FVB/J dams
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• after doxycycline treatment at P41 and P48, mice raised by FVB/J dams, and to a lesser extent raised by C57BL/6J dams, exhibit slower body weight gain compared with control mice
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• Background Sensitivity: in doxycycline-treated mice raised by FVB/J
• however, doxycycline-treated mice raised by C57BL/6J dams exhibit normal white adipose tissue weight
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• following exposure to doxycycline in utero, mice die 3 to 4 weeks after birth with giant polycystic kidneys
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• following exposure to doxycycline in utero, newborn mice exhibit fulminant cysts and giant polycystic kidneys form by 3 to 4 weeks of age
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• following exposure to doxycycline in utero, new born mice exhibit hyperplasia of the proximal and distal tubules and collecting duct epithelium
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• following exposure to doxycycline in utero, newborn mice exhibit fulminant cysts and giant polycystic kidneys form by 3 to 4 weeks of age
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| autosomal recessive polycystic kidney disease | DOID:0110861 | J:140925 | ||
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in primary podocyte cell cultures from doxycycline-treated mice
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• in doxycycline-treated mice
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• within the first 3 weeks following treatment with a high dose (50 ug/g) of doxycycline
• however, a lower doxycycline dose (15 ug/g) that produces FSGS does not affect lethality
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• within the first 3 weeks following treatment with a high dose (50 ug/g) of doxycycline
• however, a lower doxycycline dose (15 ug/g) that produces FSGS does not affect lethality
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• in doxycycline-treated mice
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• with vacuolization after 10 days in mice treated with doxycycline
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• reduced density in mice treated with doxycycline
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• from 3 weeks of age, doxycycline-treated mice exhibit focal segmental glomerulosclerosis (FSGS) with adhesions, segmental accumulation of matrix, capillary hyalinosis, loss of capillaries, and declining glomerular numbers through 13 weeks unlike control mice
• however, mice do not develop FSGS when doxycycline is administered antenatally or at 10 and 11 days after birth or when mice are treated with a low dose of doxycycline (1.5 ug/g)
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• in doxycycline-treated mice
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| focal segmental glomerulosclerosis | DOID:1312 |
OMIM:PS603278 |
J:285673 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• doxycycline-treated mice do not exhibit focal segmental glomerulosclerosis
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• doxycycline-treated mice do not exhibit focal segmental glomerulosclerosis
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• following ischemia/reperfusion injury, doxycycline-treated mice exhibit a misorganized, multi-layered, hyperproliferative epithelium and impaired recovery of renal function
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• following ischemia/reperfusion injury, doxycycline-treated mice exhibit a misorganized, multi-layered, hyperproliferative epithelium and impaired recovery of renal function
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• following ischemia/reperfusion injury, doxycycline-treated mice exhibit a misorganized, multi-layered, hyperproliferative epithelium and impaired recovery of renal function
• dividing cells of doxycycline-treated mice during kidney repair show a high shift toward mitotic spindle angles perpendicular to the epithelial plane
• however, doxycline-treated mice exhibit normal kidney histology and function under basal conditions
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• progressive in doxycycline-treated mice
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• focal segmental glomerulosclerosis in doxycycline-treated mice
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• progressive in doxycycline-treated mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 07/14/2026 MGI 6.24 |
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