Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc34a3tm1.1Nhch mutation
(1 available);
any
Slc34a3 mutation
(24 available)
Tg(Pax8-rtTA2S*M2)1Koes mutation
(3 available)
Tg(tetO-cre)LC1Bjd mutation
(2 available)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(rtTA)Awu mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Hif1atm3Rsjo mutation
(3 available);
any
Hif1a mutation
(48 available)
Tg(tetO-cre)LC1Bjd mutation
(2 available)
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cellular
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• hypoxic primary tubular epithelial cells from doxycycline treated mice fails to migrate unlike similarly treated cells from Hif1atm3Rsjo/Hif1atm3Rsjo Gt(ROSA)26Sortm1(rtTA)Awu/Gt(ROSA)26Sor+ mice
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nervous system
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• complete loss of NMDAR-mediated long term potential at dentate gyrus synapses
• however, long term potentiation at Schaffer collateral-CA1 synapses is similar to wild-type mice despite residual Cre activity in CA1 pyramidal cells
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behavior/neurological
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• mice exhibit impaired spatial working memory but normal spatial reference memory in a 3 from 6 radial arm maze task
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin2btm1Mony mutation
(0 available);
any
Grin2b mutation
(96 available)
Tg(Camk2a-Grin2c/itTA)12Rsp mutation
(1 available)
Tg(tetO-cre)LC1Bjd mutation
(2 available)
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behavior/neurological
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N |
• mice exhibit normal motor coordination and spatial reference memory acquisition in a Morris Water maze
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• mice exhibit impaired spatial reversal learning compared with control mice
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• mice exhibit a small impairment in spatial working memory in an enclosed T maze compared with control mice
• less so than Grin2btm1Mony/Grin2btm1Mony Tg(Camk2a-cre)1Gsc mice
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• less so than Grin2btm1Mony/Grin2btm1Mony Tg(Camk2a-cre)1Gsc mice
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• less so than Grin2btm1Mony/Grin2btm1Mony Tg(Camk2a-cre)1Gsc mice
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nervous system
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• in response to the Grin2b antagonist ifenprodil, mice fail to exhibit a strong reduction in NMDA excitatory postsynaptic currents and faster decay kinetics compared with control mice
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• in response to the Grin2b antagonist ifenprodil, mice fail to exhibit a strong reduction in NMDA excitatory postsynaptic currents and faster decay kinetics compared with control mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabrg2tm2Spet mutation
(0 available);
any
Gabrg2 mutation
(41 available)
Tg(Camk2a-tTA)1Mmay mutation
(8 available)
Tg(tetO-cre)LC1Bjd mutation
(2 available)
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behavior/neurological
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• induced by pentylenetetrazil in mice treated with doxycycline treatment between conception and P21 or not treated with doxycycline at all
• induced by pentylenetetrazil compared with Gabrg2tm2Spet heterozygotes
• doxycycline treatment between conception and P21 increased the time to first clonic seizure compared with mice not treated with doxycycline
• however, no seizure kindling effect is observed
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nervous system
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• induced by pentylenetetrazil in mice treated with doxycycline treatment between conception and P21 or not treated with doxycycline at all
• induced by pentylenetetrazil compared with Gabrg2tm2Spet heterozygotes
• doxycycline treatment between conception and P21 increased the time to first clonic seizure compared with mice not treated with doxycycline
• however, no seizure kindling effect is observed
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adipose tissue
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• Background Sensitivity: in doxycycline-treated mice raised by FVB/J
• however, doxycycline-treated mice raised by C57BL/6J dams exhibit normal white adipose tissue weight
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• Background Sensitivity: in doxycycline-treated mice raised by FVB/J
• however, doxycycline-treated mice raised by C57BL/6J dams exhibit normal white adipose tissue weight
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• Background Sensitivity: visceral, epididymal and subcutaneous white adipose tissue in doxycycline-treated mice raised by FVB/J
• however, doxycycline-treated mice raised by C57BL/6J dams exhibit normal white adipose tissue weight
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homeostasis/metabolism
behavior/neurological
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• Background Sensitivity: in an elevated plus maze and open field test, doxycycline-treated mice raised by FVB/J dams exhibit increased anxiety-related behaviors compared with similarly fostered control mice
• however, doxycycline-treated mice fostered by C57BL/6J dams exhibit normal anxiety
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• doxycycline-treated mice raised by C57BL/6J dams exhibit decreased total distance traveled in an open field compared with control mice and doxycycline-treated mice raised by FVB/J dams
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growth/size/body
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• after doxycycline treatment at P41 and P48, mice raised by FVB/J dams, and to a lesser extent raised by C57BL/6J dams, exhibit slower body weight gain compared with control mice
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integument
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• Background Sensitivity: in doxycycline-treated mice raised by FVB/J
• however, doxycycline-treated mice raised by C57BL/6J dams exhibit normal white adipose tissue weight
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mortality/aging
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• following exposure to doxycycline in utero, mice die 3 to 4 weeks after birth with giant polycystic kidneys
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renal/urinary system
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• following exposure to doxycycline in utero, newborn mice exhibit fulminant cysts and giant polycystic kidneys form by 3 to 4 weeks of age
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• following exposure to doxycycline in utero, new born mice exhibit hyperplasia of the proximal and distal tubules and collecting duct epithelium
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growth/size/body
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• following exposure to doxycycline in utero, newborn mice exhibit fulminant cysts and giant polycystic kidneys form by 3 to 4 weeks of age
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation
(8 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Tg(NPHS2-rtTA2*M2)1Jbk mutation
(1 available)
Tg(tetO-cre)LC1Bjd mutation
(2 available)
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cellular
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• in primary podocyte cell cultures from doxycycline-treated mice
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homeostasis/metabolism
mortality/aging
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• within the first 3 weeks following treatment with a high dose (50 ug/g) of doxycycline
• however, a lower doxycycline dose (15 ug/g) that produces FSGS does not affect lethality
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renal/urinary system
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• in doxycycline-treated mice
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• with vacuolization after 10 days in mice treated with doxycycline
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• reduced density in mice treated with doxycycline
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• from 3 weeks of age, doxycycline-treated mice exhibit focal segmental glomerulosclerosis (FSGS) with adhesions, segmental accumulation of matrix, capillary hyalinosis, loss of capillaries, and declining glomerular numbers through 13 weeks unlike control mice
• however, mice do not develop FSGS when doxycycline is administered antenatally or at 10 and 11 days after birth or when mice are treated with a low dose of doxycycline (1.5 ug/g)
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• in doxycycline-treated mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation
(8 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Tg(NPHS2-rtTA2*M2)1Jbk mutation
(1 available)
Tg(tetO-cre)LC1Bjd mutation
(2 available)
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renal/urinary system
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N |
• doxycycline-treated mice do not exhibit focal segmental glomerulosclerosis
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation
(8 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Tg(PODXL-rtTA*M2)#Mjmr mutation
(0 available)
Tg(tetO-cre)LC1Bjd mutation
(2 available)
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renal/urinary system
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N |
• doxycycline-treated mice do not exhibit focal segmental glomerulosclerosis
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdc42tm1Brak mutation
(0 available);
any
Cdc42 mutation
(43 available)
Tg(Pax8-rtTA2S*M2)1Koes mutation
(3 available)
Tg(tetO-cre)LC1Bjd mutation
(2 available)
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homeostasis/metabolism
renal/urinary system
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• following ischemia/reperfusion injury, doxycycline-treated mice exhibit a misorganized, multi-layered, hyperproliferative epithelium and impaired recovery of renal function
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• following ischemia/reperfusion injury, doxycycline-treated mice exhibit a misorganized, multi-layered, hyperproliferative epithelium and impaired recovery of renal function
• dividing cells of doxycycline-treated mice during kidney repair show a high shift toward mitotic spindle angles perpendicular to the epithelial plane
• however, doxycline-treated mice exhibit normal kidney histology and function under basal conditions
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(NPHS2-rtTA2*M2)1Jbk mutation
(1 available)
Tg(tetO-cre)LC1Bjd mutation
(2 available)
Wt1tm1.1Ceng mutation
(0 available);
any
Wt1 mutation
(34 available)
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renal/urinary system
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• progressive in doxycycline-treated mice
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• focal segmental glomerulosclerosis in doxycycline-treated mice
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homeostasis/metabolism
Analysis Tools