Gabrg2^tm2Spet
Targeted Allele Detail

Summary

• Symbol: Gabrg2^tm2Spet
• Name: gamma-aminobutyric acid type A receptor, subunit gamma 2; targeted mutation 2, Steven Petrou
• MGI ID: MGI:5474655
• Synonyms: Gabrg2^Qneo, gamma2^Q43neo
• Gene: Gabrg2 Location: Chr11:41801030-41891684 bp, - strand Genetic Position: Chr11, 24.8 cM
• Alliance: Gabrg2^tm2Spet page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:127120
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutation: Insertion
• Mutation details: The coding region was replaced with a coding region containing substitution that results in an amino acid substution of a glutamine for an arginine at position 43 (R43Q), 4 additional silent mutations (not identified) and a floxed neo cassette. This allele is hypomorphic and was used to generate Gabrg2^tm1Spet. QPCR confirms reduced transcript expression at P15 and P66. (J:127120)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gabrg2 Mutation: 41 strains or lines available

References

• Original: J:127120 Tan HO, et al., Reduced cortical inhibition in a mouse model of familial childhood absence epilepsy. Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17536-41
• All: 4 reference(s)