Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgap35tm1Jset mutation
(1 available);
any
Arhgap35 mutation
(70 available)
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Hypoplastic and glomerulocystic kidneys in Arhgap35tm1Jset/Arhgap35tm1Jset mutants
mortality/aging
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• early perinatal lethality
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renal/urinary system
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• 100% of E17.5 embryos display hypodysplastic kidneys
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• cystic glomeruli at E17.5
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• E17.5 kidneys exhibit hypoplasia or agenesis
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• E17.5 kidneys exhibit hypoplasia or agenesis
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nervous system
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• 44% of E17.5 embryos display neural tube closure defects (exencephaly and spina bifida)
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embryo
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• 44% of E17.5 embryos display neural tube closure defects (exencephaly and spina bifida)
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growth/size/body
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• cystic glomeruli at E17.5
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgap35tm1Jset mutation
(1 available);
any
Arhgap35 mutation
(70 available)
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mortality/aging
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• 95% of homozygotes die within 2 days of birth
• remaining homozygous mice all die within 3 weeks
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vision/eye
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• a defect in closure of the optic fissure leads to coloboma
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• eyes smaller than normal
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• abnormal folding of the retina
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nervous system
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• reduced apical constriction of neuroepithelial cells in presumptive floor plate is sometimes seen
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• 30% of E10.5 embryos have severe cranial neural tube closure defects; these embryos have an open neural tube extending from the developing forebrain to the presumptive hindbrain
• no abnormal closure in caudal neural tube
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• in the caudal neural tube, suggesting a mild closure defect in the spinal cord
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• corpus callosum completely lacking
• substantial cleft between cerebral hemispheres
• fibers normally crossing corpus callosum form neuromas (Probst bundles)
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• axonal projections of the posterior limb of the anterior commisure fail to reach the midline and sometimes project ventrally
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• disorganized layering of cerebral cortex
(J:65296)
• diffuse organization of neurons in the cortical plate
(J:65296)
• intermediate zone subcortical axon tracts reduced in thickness
(J:68904)
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• fascicles of subcortical axon tracts sometimes ectopically invade cortical plate
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• in about 30% of newborns
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• ganglion diffuse
• abnormal sprouting of fine rootlets
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• abnormal sprouting of fine rootlets
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• trigeminal nerve more diffuse
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growth/size/body
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• about 2% show a failed fusion of the body wall at the navel
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• mice surviving more than 2 days are runted
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embryo
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• reduced apical constriction of neuroepithelial cells in presumptive floor plate is sometimes seen
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|
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• 30% of E10.5 embryos have severe cranial neural tube closure defects; these embryos have an open neural tube extending from the developing forebrain to the presumptive hindbrain
• no abnormal closure in caudal neural tube
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• in the caudal neural tube, suggesting a mild closure defect in the spinal cord
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pigmentation
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgap35m1Bchd mutation
(0 available);
any
Arhgap35 mutation
(70 available)
Arhgap35tm1Jset mutation
(1 available);
any
Arhgap35 mutation
(70 available)
|
|
|
Hypoplastic and glomerulocystic kidneys in Arhgap35tm1Jset/Arhgap35m1Bchd mutants
mortality/aging
|
|
• early perinatal lethality
|
renal/urinary system
|
|
• 100% of E17.5 embryos display hypodysplastic kidneys
|
|
|
• cystic glomeruli at E17.5
|
|
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• E17.5 kidneys exhibit hypoplasia or agenesis
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|
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• E17.5 kidneys exhibit hypoplasia or agenesis
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nervous system
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• 38% of E17.5 embryos display neural tube closure defects (exencephaly and spina bifida)
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embryo
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• 38% of E17.5 embryos display neural tube closure defects (exencephaly and spina bifida)
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growth/size/body
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• cystic glomeruli at E17.5
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Analysis Tools