All Phenotypes Epha2<Gt(ROSABetageo)CN3Yiw> MGI Mouse

abnormal tail morphology ( J:69393 )

• abnormal blood vessel formation in the tails

• ectopic tail vertebra formation

short tail ( J:69393 )

• varying degrees of short tails, first seen around E12.5-13.5

kinked tail ( J:69393 )

• 40% exhibit varying degrees of kinky tails, first seen around E12.5-13.5

abnormal axial mesoderm morphology ( J:69393 )

• aberrant axial mesoderm formation

abnormal neural tube morphology ( J:69393 )

• the wall of the neural tube in tails is thickened and multi-layered

split notochord ( J:69393 )

• notochord is abnormally bifurcated at the caudal end between E11.5 and E12.5 and the bifurcated notochords are abnormally intertwined

• notochordal cells are spread broadly into the tail bud

abnormal neural tube morphology ( J:69393 )

• the wall of the neural tube in tails is thickened and multi-layered

abnormal vascular development ( J:69393 )

• abnormal blood vessel formation in tails, with the number of blood vessels changed and larger vessel caliber

• ectopic tail vertebra formation

abnormal sclerotome morphology ( J:69393 )

• ectopic slerotomes form at the caudal tail where the bifurcated notochords form

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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