Analysis Tools|
Allele Symbol Allele Name Allele ID |
Xdhtm1Mrc targeted mutation 1, Mario R Capecchi MGI:2448161 |
| Summary |
2 genotypes |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• homozygotes fail to live beyond 6 weeks of age
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• homozygotes are runted
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
 |
• heterozygotes display premature involution of the mammary gland at lactation day 11
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• at lactation day 11, the heterozygous mammary epithelium shows severe cell shedding and tissue fragmentation with loss of epithelial tissue volume and premature tissue involution
• by lactation day 13, an overall collapse of mammary epithelial tissue is observed
• only milk secreting alveoli are affected, while ducts, which transport secretions to the exterior of the gland, appear normal
• mammary tissue destruction is independent of a defect in lactogenic hormones and correlates with the time course of pup starvation
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• heterozygotes show defective enveloping of milk fat droplets with the apical mammary epithelial membrane, resulting in impaired secretion of droplets into milk
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• heterozygotes are unable to maintain lactation due to failure to secrete fat droplets into milk; as a result, their pups die of starvation within 2 weeks postpartum
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• pups nursed by heterozygous mothers begin to appear visibly malnourished by P6
• by P12, pups are emaciated, and by P13, remaining pups display less than 50% of wild-type body weight
• pups from heterozygous females can be raised normally by wild-type mothers
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• pups born to heterozygous females are devoid of adipose tissue e.g. brown fat and mammary fat pads
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• pups born to heterozygous females show reduced skeletal muscle volume, consistent with starvation
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• heterozygotes display premature involution of the mammary gland at lactation day 11
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|
• at lactation day 11, the heterozygous mammary epithelium shows severe cell shedding and tissue fragmentation with loss of epithelial tissue volume and premature tissue involution
• by lactation day 13, an overall collapse of mammary epithelial tissue is observed
• only milk secreting alveoli are affected, while ducts, which transport secretions to the exterior of the gland, appear normal
• mammary tissue destruction is independent of a defect in lactogenic hormones and correlates with the time course of pup starvation
|
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• heterozygotes show defective enveloping of milk fat droplets with the apical mammary epithelial membrane, resulting in impaired secretion of droplets into milk
|
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• heterozygotes are unable to maintain lactation due to failure to secrete fat droplets into milk; as a result, their pups die of starvation within 2 weeks postpartum
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/30/2025 MGI 6.24 |
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