Xdh^tm1Mrc
Targeted Allele Detail

Summary

• Symbol: Xdh^tm1Mrc
• Name: xanthine dehydrogenase; targeted mutation 1, Mario R Capecchi
• MGI ID: MGI:2448161
• Synonyms: XOR^-
• Gene: Xdh Location: Chr17:74190890-74257191 bp, - strand Genetic Position: Chr17, 45.25 cM
• Alliance: Xdh^tm1Mrc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80993
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A self-excising neomycin resistance cassette was inserted into exon 3 of the endogenous gene. The targeting construct was comprised of sequence encoding GFP followed by a floxed region containing a mouse testes-specific Ace promoter fused to the cre recombinase and neomycin resistance genes. The floxed region undergoes self-excision during spermiogenesis, resulting in the production of protein encoded by exons 1 and 2 and a 5' portion of exon 3 fused to GFP. (J:80993)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Xdh Mutation: 100 strains or lines available

References

• Original: J:80993 Vorbach C, et al., The housekeeping gene xanthine oxidoreductase is necessary for milk fat droplet enveloping and secretion: gene sharing in the lactating mammary gland. Genes Dev. 2002 Dec 15;16(24):3223-35
• All: 1 reference(s)