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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(LCKprBCL2L1)12Sjk
transgene insertion 12, Stanley J Korsmeyer
MGI:2447593
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Smarca4tm1.2Pcn/Smarca4tm1Tich
Tg(Lck-cre)1Cwi/0
Tg(LCKprBCL2L1)12Sjk/0 		involves: 129 MGI:3830512
cn2
 		Smarca4tm1.2Pcn/Smarca4tm1.2Pcn
Tg(Lck-cre)1Cwi/0
Tg(LCKprBCL2L1)12Sjk/0 		Not Specified MGI:3830514
cx3
 		Prkcqtm1Litt/Prkcqtm1Litt
Tg(LCKprBCL2L1)12Sjk/0 		involves: 129P2/OlaHsd * C57BL/6 MGI:4843486
cx4
 		Mirc14tm1.2Flv/Mirc14tm1.2Flv
Tg(LCKprBCL2L1)12Sjk/0 		involves: C57BL/6 * C57BL/6N * FVB/N * SJL MGI:5529021


Genotype
MGI:3830512
cn1
Allelic
Composition		 Smarca4tm1.2Pcn/Smarca4tm1Tich
Tg(Lck-cre)1Cwi/0
Tg(LCKprBCL2L1)12Sjk/0
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smarca4tm1.2Pcn mutation (1 available); any Smarca4 mutation (109 available)
Smarca4tm1Tich mutation (0 available); any Smarca4 mutation (109 available)
Tg(Lck-cre)1Cwi mutation (3 available)
Tg(LCKprBCL2L1)12Sjk mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell morphology ( J:144072 )
• unlike in Smarca4tm1Grc/Smarca4tm1Grc Tg(Lck-cre)1Cwi mice, a CD4-CD8+ population is not observed
• 25% of the post-DN3 population is composed of CD4-DN4 cells compared to 9% in Smarca4tm1Grc/Smarca4tm1Grc Tg(Lck-cre)1Cwi Tg(LCKprBCL2L1)12Sjk mice
• 39% of the post-DN3 population is composed of CD4+DN4 cells compared to 52% in Smarca4tm1Grc/Smarca4tm1Grc Tg(Lck-cre)1Cwi Tg(LCKprBCL2L1)12Sjk mice
• mice exhibit two CD4+ populations with different levels of CD4 expression

hematopoietic system
abnormal T cell morphology ( J:144072 )
• unlike in Smarca4tm1Grc/Smarca4tm1Grc Tg(Lck-cre)1Cwi mice, a CD4-CD8+ population is not observed
• 25% of the post-DN3 population is composed of CD4-DN4 cells compared to 9% in Smarca4tm1Grc/Smarca4tm1Grc Tg(Lck-cre)1Cwi Tg(LCKprBCL2L1)12Sjk mice
• 39% of the post-DN3 population is composed of CD4+DN4 cells compared to 52% in Smarca4tm1Grc/Smarca4tm1Grc Tg(Lck-cre)1Cwi Tg(LCKprBCL2L1)12Sjk mice
• mice exhibit two CD4+ populations with different levels of CD4 expression

endocrine/exocrine glands




Genotype
MGI:3830514
cn2
Allelic
Composition		 Smarca4tm1.2Pcn/Smarca4tm1.2Pcn
Tg(Lck-cre)1Cwi/0
Tg(LCKprBCL2L1)12Sjk/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smarca4tm1.2Pcn mutation (1 available); any Smarca4 mutation (109 available)
Tg(Lck-cre)1Cwi mutation (3 available)
Tg(LCKprBCL2L1)12Sjk mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell morphology ( J:144072 )
• 9% of the post-DN3 population is composed of CD4-DN4 cells compared to 25% in Smarca4tm1Tich/Smarca4tm1Tich Tg(Lck-cre)1Cwi Tg(LCKprBCL2L1)12Sjk mice
• 52% of the post-DN3 population is composed of CD4+DN4 cells compared to 39% in Smarca4tm1Tich/Smarca4tm1Tich Tg(Lck-cre)1Cwi Tg(LCKprBCL2L1)12Sjk mice
increased thymocyte number ( J:144072 )
• 8-fold compared to in Smarca4tm1Gcr/Smarca4tm1Tich Tg(Lck-cre)1Cwi mice
increased double-negative T cell number ( J:144072 )
• the DN2 population increases
• the DN3 population is rescued but is growth arrested
• the post-DN3 population is increased
decreased double-positive T cell number ( J:144072 )
• relative to DN4 cellularity

hematopoietic system
abnormal T cell morphology ( J:144072 )
• 9% of the post-DN3 population is composed of CD4-DN4 cells compared to 25% in Smarca4tm1Tich/Smarca4tm1Tich Tg(Lck-cre)1Cwi Tg(LCKprBCL2L1)12Sjk mice
• 52% of the post-DN3 population is composed of CD4+DN4 cells compared to 39% in Smarca4tm1Tich/Smarca4tm1Tich Tg(Lck-cre)1Cwi Tg(LCKprBCL2L1)12Sjk mice
increased thymocyte number ( J:144072 )
• 8-fold compared to in Smarca4tm1Gcr/Smarca4tm1Tich Tg(Lck-cre)1Cwi mice
increased double-negative T cell number ( J:144072 )
• the DN2 population increases
• the DN3 population is rescued but is growth arrested
• the post-DN3 population is increased
decreased double-positive T cell number ( J:144072 )
• relative to DN4 cellularity

endocrine/exocrine glands
increased thymocyte number ( J:144072 )
• 8-fold compared to in Smarca4tm1Gcr/Smarca4tm1Tich Tg(Lck-cre)1Cwi mice




Genotype
MGI:4843486
cx3
Allelic
Composition		 Prkcqtm1Litt/Prkcqtm1Litt
Tg(LCKprBCL2L1)12Sjk/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkcqtm1Litt mutation (3 available); any Prkcq mutation (51 available)
Tg(LCKprBCL2L1)12Sjk mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:141128 )
N
• apoptosis of CD3 and CD28 stimulated T cells is normal

hematopoietic system




Genotype
MGI:5529021
cx4
Allelic
Composition		 Mirc14tm1.2Flv/Mirc14tm1.2Flv
Tg(LCKprBCL2L1)12Sjk/0
Genetic
Background		 involves: C57BL/6 * C57BL/6N * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc14tm1.2Flv mutation (0 available); any Mirc14 mutation (1 available)
Tg(LCKprBCL2L1)12Sjk mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased NK T cell number ( J:203157 )
• in the thymus, spleen and liver of mice treated with alpha- galactosylceramide CD1d1 tetramer

immune system
decreased NK T cell number ( J:203157 )
• in the thymus, spleen and liver of mice treated with alpha- galactosylceramide CD1d1 tetramer




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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory