Phenotypes associated with this allele

• Allele Symbol: Tg(CNTN2-CNTN1)1Gnn
• Allele Name: transgene insertion 1, Gianfranco Gennarini
• Allele ID: MGI:2445836
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(CNTN2-CNTN1)1Gnn/0	involves: C57BL/10 * CBA	MGI:2652345

Genotype
MGI:2652345

tg1

• Allelic Composition: Tg(CNTN2-CNTN1)1Gnn/0
• Genetic Background: involves: C57BL/10 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal cerebellum morphology ( J:80098 )

abnormal Purkinje cell differentiation ( J:80098 )

• delayed Purkinje cell terminal differentiation, however, premature elevation of calbindin expression suggests that aspects of early differentiation may occur prematurely

thin external granule cell layer ( J:80098 )

• the EGL was most severely affected at postnatal day 3 but recovers to normal size by P11

• developmentally regulated changes in granule cell proliferation in the EGL, with a decrease in early development followed by a compensatory increase at the end of the first postnatal week

abnormal cerebellar granule cell morphology ( J:80098 )

• developmentally regulated changes in granule cell proliferation, with a decrease in early development followed by a compensatory increase at the end of the first postnatal week

thin cerebellar granule layer ( J:80098 )

• at postnatal day 8, IGL was reduced by almost 50%, followed by recovery after postnatal day 16

• developmentally regulated changes in cell death in the inner granule layer, with an increase in early development (P3) followed by a decrease at the end of the first postnatal week

thin cerebellar molecular layer ( J:80098 )

• at postnatal day 8, molecular layer was reduced by almost 50%, followed by recovery after postnatal day 16

small cerebellum ( J:80098 )

• reduced cerebellum size between postnatal days 3 - 16, that is indistinguishable from wild-type at postnatal day 30

abnormal neurite morphology ( J:80098 )

• cultures from cerebella exhibit shorter neurites that cover a lower surface area than controls and neurites display a tendency to fasciculate more than in controls

abnormal Purkinje cell dendrite morphology ( J:80098 )

• reduced arborization of Purkinje cell dendrites at P3, with striking reductions at P8 and P11, but by P16, Purkinje cells essentially appear normal

cellular

abnormal Purkinje cell differentiation ( J:80098 )

• delayed Purkinje cell terminal differentiation, however, premature elevation of calbindin expression suggests that aspects of early differentiation may occur prematurely